V
Véronique Gouverneur
Researcher at University of Oxford
Publications - 253
Citations - 15356
Véronique Gouverneur is an academic researcher from University of Oxford. The author has contributed to research in topics: Catalysis & Allylic rearrangement. The author has an hindex of 52, co-authored 240 publications receiving 13449 citations. Previous affiliations of Véronique Gouverneur include Claude Bernard University Lyon 1 & University of California, Los Angeles.
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Fluorine in medicinal chemistry.
TL;DR: This tutorial review provides a sampling of renowned fluorinated drugs and their mode of action with a discussion clarifying the role and impact of fluorine substitution on drug potency.
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18F-Labeling of Arenes and Heteroarenes for Applications in Positron Emission Tomography
TL;DR: This piece reviews all of the reactions known to date to install the (18)F substituent and other key ( 18)F-motifs of medicinal relevance onto (hetero)arenes and suggests the radiochemical space available for PET applications will expand rapidly in the near future.
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Catalytic hydrotrifluoromethylation of unactivated alkenes.
Satoshi Mizuta,Stefan Verhoog,Keary M. Engle,Tanatorn Khotavivattana,Miriam L. O’Duill,Katherine Wheelhouse,Gerasimos A. Rassias,Maurice Médebielle,Véronique Gouverneur +8 more
TL;DR: A visible-light-mediated hydrotrifluoromethylation of unactivated alkenes that uses the Umemoto reagent as the CF(3) source and MeOH as the reductant is disclosed, characterized by its operational simplicity and functional group tolerance.
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Organocatalyzed Enantioselective Fluorocyclizations
Oscar Lozano,George Blessley,Teresa Martínez del Campo,Amber L. Thompson,Guy T. Giuffredi,Michela Bettati,Matthew D. Walker,Richard A. Borman,Véronique Gouverneur +8 more
TL;DR: More than twenty examples for this cascade fluorination-cyclization, which is catalyzed by cinchona alkaloids and employs N-fluorobenzenesulfonimide as the electrophilic fluorine source have been explored, and an unprecedented catalytic asymmetric difluorocyclization has also been identified.
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Transition metal catalysis and nucleophilic fluorination
TL;DR: A striking recent development is the successful design, synthesis and applications of a fluoride-derived electrophilic late stage fluorination reagent that could greatly benefit preclinical and clinical PET imaging.