Showing papers by "Peter S.J. Lees published in 2005"
TL;DR: This study confirms the viability of in situ remediation of soils in urban areas where children are at risk of high Pb exposure from lead in paint, dust and soil.
76 citations
TL;DR: This research presents a meta-analyses of the immune system’s response to exposure to carbon dioxide and shows clear patterns of decline in the immune systems of mice bitten by carbon monoxide-causing bacteria.
Abstract: Jeanne Manson, Michael J. Brabec, Judy Buelke-Sam, Gary P. Carlson, Robert E. Chapin, John B. Favor, Lawrence J. Fischer, Dale Hattis, Peter S.J. Lees, Sally Perreault-Darney, Joe Rutledge, Thomas J. Smith, Raymond R. Tice and Peter Working University of Pennsylvania, Philadelphia, Pennsylvania Eastern Michigan University, Ypsilanti, Michigan Toxicology Services, Greenfield, Indiana Purdue University, West Lafayette, Indiana Pfizer, Inc., Groton, Connecticut GSF-National Research Center for Environment and Health, Neuherberg, Germany Michigan State University, Lansing, Michigan Clark University, Worcester, Massachusetts Johns Hopkins University, Baltimore, Maryland U.S. Environmental Protection Agency (EPA), Research Triangle Park, North Carolina Children’s Hospital, Seattle, Washington Harvard School of Public Health, Boston, Massachusetts Integrated Laboratory Systems, Inc., Research Triangle Park, North Carolina Cell Genesys, Inc., South San Francisco, California
60 citations
TL;DR: The analysis of settled dust collected using a cyclone device from streets, sidewalks, and alleys within 100 m of study sites before, immediately after, and 1 month after demolition found acute increases in Pb loadings and dust loadings after demolition and debris removal that are of public health concern.
55 citations
TL;DR: Comparing quantitative PCR (qPCR) enumeration with direct epifluorescent microscopic filter counts of conidia collected on filters confirmed that qPCR provides sensitive and accurate quantification of DNA from airborne conidia collection on filters.
Abstract: This study used green fluorescent protein (GFP)-expressing Aspergillus fumigatus conidia to compare quantitative PCR (qPCR) enumeration with direct epifluorescent microscopic filter counts of conidia collected on filters in a test chamber. In separate experiments this study initially compared white versus fluorescent light microscopy for counting A. fumigatus conidia, then compared fluorescent microscopy counting of corresponding filter halves, and finally compared qPCR enumeration to counting by fluorescent light microscopy. The use of GFP-expressing conidia with epifluorescent microscopy yielded significantly higher conidia counts (p = 0.026, n = 41, mean of 4.1 conidia per counting field) and 40% faster counting times when compared to conventional counting using white light microscopy. GFP-expressing conidia were aerosolized in a test chamber and collected onto filters. Filters were divided in half and GFP-expressing conidia enumerated. There was no significant difference in the average conidia count p...
9 citations