P
Peter Schmid
Researcher at Novartis
Publications - 19
Citations - 953
Peter Schmid is an academic researcher from Novartis. The author has contributed to research in topics: Transforming growth factor & Amyloid beta. The author has an hindex of 13, co-authored 19 publications receiving 875 citations. Previous affiliations of Peter Schmid include Swiss Tropical and Public Health Institute.
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Journal ArticleDOI
LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice
Martin C. Herzig,Carine Kolly,Elke Persohn,Diethilde Theil,Tatjana Schweizer,Thomas Hafner,Christine Stemmelen,Troxler Thomas J,Peter Schmid,Simone Danner,Christian Schnell,Matthias Mueller,Bernd Kinzel,Armelle Grevot,Federico Bolognani,Martina Stirn,Rainer Kuhn,Klemens Kaupmann,P. Herman van der Putten,Giorgio Rovelli,Derya R. Shimshek +20 more
TL;DR: A role for LRRK2 in kidney and lung physiology is demonstrated and it is shown that LRRk2 kinase function affects L RRK2 protein steady-state levels thereby altering putative scaffold/GTPase activity.
Journal ArticleDOI
TGF‐βS and TGF‐β type II receptor in human epidermis: Differential expression in acute and chronic skin wounds
Peter Schmid,David Cox,Graeme Bilbe,Mcmaster Gary Kent,Christopher A. Morrison,Hannes B. Stähelin,Nicholas J. Luscher,Walter O. Seiler +7 more
TL;DR: It is suggested that constitutive expression of TGF‐β3 is important for maintenance of epidermal differentiation and that an induction of T GF‐β1 expression is essential for re‐epithelialization of human skin wounds.
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A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice
Ulf Neumann,Heinrich Rueeger,Rainer Machauer,Siem Jacob Veenstra,Rainer Martin Lueoend,Marina Tintelnot-Blomley,Grit Laue,Karen Beltz,Barbara Vogg,Peter Schmid,Peter Schmid,Wilfried Frieauff,Derya R. Shimshek,Matthias Staufenbiel,Matthias Staufenbiel,Laura H. Jacobson,Laura H. Jacobson +16 more
TL;DR: In this article, NB-360, a potent and brain penetrable BACE-1 inhibitor can completely block the progression of amyloid-β deposition in the brains of APP transgenic mice, a model for Alzheimer's pathology.
Journal ArticleDOI
Transient production of TGF-beta 2 by postnatal cerebellar neurons and its effect on neuroblast proliferation.
TL;DR: The expression of TGF‐β isoforms was investigated in the postnatal and adult mouse brain and data suggest that T GF‐β2 is involved in the regulation of postnatal development of the cerebellum.
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High LRRK2 levels fail to induce or exacerbate neuronal alpha-synucleinopathy in mouse brain.
Martin C. Herzig,Michael Bidinosti,Tatjana Schweizer,Thomas Hafner,Christine Stemmelen,Andreas Weiss,Simone Danner,Nella Vidotto,Daniela Stauffer,Carmen Barske,Franziska Mayer,Peter Schmid,Giorgio Rovelli,P. Herman van der Putten,Derya R. Shimshek +14 more
TL;DR: In many neurons high LRRK2 levels are well tolerated and not sufficient to drive or exacerbate neuronal α-synucleinopathy, suggesting that L RRK2 steady-state abundance of the protein also plays a determining role in molecular pathogenesis.