Graeme Bilbe

TL;DR: An antagonist for the metabotropic glutamate receptor may improve symptoms in patients with fragile X syndrome whose FMR1 promoters are fully methylated, a sign that gene expression is completely silenced, and provides the basis for a larger study to test whether methylation can serve as a predictor of a positive antagonist response in a population of patients with Fragile X syndrome.

TL;DR: Thy1 transgene expression of wild-type human α-synuclein resulted in similar pathological changes, thus supporting a central role for mutant and wild- type α- Synuclein in familial and idiotypic forms of diseases with neuronal α- synucleinopathy and Lewy pathology.

TL;DR: Northern blot analysis showed that cathepsin K mRNA is expressed at high levels in some osteoarthritic hip bones and at a very high level in osteoclastoma compared to very low levels in other tissues, suggesting that cat hepsinK is closely involved in human osteoclastic bone resorption.

TL;DR: All three isoforms were expressed in bone tissues but showed distinct patterns of expression both spatially and temporally, and TGF beta 3 was strongest in prevertebral tissue, in some mesothelia and in lung epithelia.

TL;DR: Human cathepsin K is a novel cysteine protease previously reported to be restricted in its expression to osteoclasts that may contribute to the invasive potential of breast cancer cells, including those that metastasize to bone.