Karen Beltz

TL;DR: The results have proved the concept that a nucleoside inhibitor could be developed for potential treatment of flavivirus infections and suppressed peak viremia, reduced cytokine elevation, and completely prevented the infected mice from death.

TL;DR: In healthy adults ≥ 60 years old, treatment with CNP520 was safe and well tolerated and resulted in robust and dose‐dependent Aβ reduction in the cerebrospinal fluid, and long‐term, pivotal studies with C NP520 have been initiated in the Generation Program.

TL;DR: In this article, NB-360, a potent and brain penetrable BACE-1 inhibitor can completely block the progression of amyloid-β deposition in the brains of APP transgenic mice, a model for Alzheimer's pathology.

TL;DR: BACE2-mediated inhibition of PMEL17 proteolytic processing in vitro in mouse and human melanocytes is confirmed and it is demonstrated that BACE2 as well as additional BACE1 inhibition affects melanosome maturation and induces hair depigmentation in mice.

TL;DR: The results of a series of toxicology studies in rat and dog species using MLT-943 confirm the therapeutic potential of MALT1 protease inhibitors but highlight the safety risks and challenges to consider before potential application of such inhibitors into the clinic.