P
Peter T. Southwell-Keely
Researcher at University of New South Wales
Publications - 33
Citations - 424
Peter T. Southwell-Keely is an academic researcher from University of New South Wales. The author has contributed to research in topics: Sulfenamide & Vitamin E. The author has an hindex of 12, co-authored 33 publications receiving 408 citations. Previous affiliations of Peter T. Southwell-Keely include The Heart Research Institute.
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Is α-tocopherol a reservoir for α-tocopheryl hydroquinone?
TL;DR: In this paper, the authors studied the properties of the alpha-tocopherol model compound, 2,2,5,7,8-pentamethyl-6-chromanol (PH) by t-butyl hydroperoxide in chloroform and showed that the main products were spirodimer (PSD) and spirotrimer (PST).
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Cytotoxicity of tocopherols and their quinones in drug-sensitive and multidrug-resistant leukemia cells
David G. Cornwell,Kenneth H. Jones,Zongcheng Jiang,Laura E. Lantry,Peter T. Southwell-Keely,Indrajati Kohar,Donald E. Thornton +6 more
TL;DR: Tocopherylquinones represent a new class of alkylating electrophilic quinones that function as highly cytotoxic agents and escape multidrug resistance in acute lymphoblastic leukemia cell lines.
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Oxidations of vitamin e alpha tocopherol and its model compound 2 2 5 7 8 pentamethyl 6 hydroxychroman a new dimer
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Oxidation of 3-hydroxyanthranilic acid to the phenoxazinone cinnabarinic acid by peroxyl radicals and by compound I of peroxidases or catalase.
TL;DR: Since 3-hydroxyanthranilic acid (3HAA) is a powerful radical scavenger, its reaction with peroxyl radicals was investigated further and formation of cinnabarinic acid (CA) was observed when 3HAA was added to performed compound I of horseradish peroxidase (HRPO) or catalytic amounts of either HRPO, myeloperoxidases, or bovine liver catalase together with glucose/glucose
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Probucol protects against hypochlorite-induced endothelial dysfunction: identification of a novel pathway of probucol oxidation to a biologically active intermediate.
TL;DR: Results show that both probucol and DTBP react with HOCl and protect against HOCl-induced endothelial dysfunction, although direct scavenging of HOCl is unlikely to be responsible for the vascular protection by the two compounds.