P
Petrine Wellendorph
Researcher at University of Copenhagen
Publications - 100
Citations - 2883
Petrine Wellendorph is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Receptor & GABAA receptor. The author has an hindex of 27, co-authored 83 publications receiving 2573 citations. Previous affiliations of Petrine Wellendorph include University of Turin & ACADIA Pharmaceuticals Inc..
Papers
More filters
Journal ArticleDOI
Five-Membered N-Heterocyclic Scaffolds as Novel Amino Bioisosteres at γ-Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters.
Alessandro Giraudo,Alessandro Giraudo,Jacob Krall,Francesco Bavo,Francesco Bavo,Birgitte Nielsen,Kenneth T. Kongstad,Barbara Rolando,Rossella De Blasio,David E. Gloriam,Rebekka Löffler,Louise Thiesen,Kasper Harpsøe,Karla Frydenvang,Donatella Boschi,Petrine Wellendorph,Marco Lucio Lolli,Anders A. Jensen,Bente Frølund +18 more
TL;DR: It is illustrated how subtle structural differences in these novel amino GABA bioisosteres can result in diverse pharmacological profiles in terms of selectivity and efficacy.
Journal ArticleDOI
Discovery of 2-(Imidazo[1,2- b]pyridazin-2-yl)acetic Acid as a New Class of Ligands Selective for the γ-Hydroxybutyric Acid (GHB) High-Affinity Binding Sites.
Jacob Krall,Francesco Bavo,Francesco Bavo,Christina Birkedahl Falk-Petersen,Claus H. Jensen,Julie O. Nielsen,Yongsong Tian,Valeria Anglani,Kenneth T. Kongstad,Louise Piilgaard,Birgitte Nielsen,David E. Gloriam,Jan Kehler,Anders A. Jensen,Kasper Harpsøe,Petrine Wellendorph,Bente Frølund +16 more
TL;DR: It is highlighted that gabazine interacts with the high-affinity GHB and orthosteric GABAA receptor binding sites differently and that distinct analogues can be generated to select between them.
Journal ArticleDOI
Pharmacological characterization of [3H]ATPCA as a substrate for studying the functional role of the betaine/GABA transporter 1 and the creatine transporter
Anas Al-Khawaja,Anne S. Haugaard,Aleš Marek,Rebekka Löffler,Louise Thiesen,Mònica Santiveri,Maria Damgaard,Christoffer Bundgaard,Bente Frølund,Petrine Wellendorph +9 more
TL;DR: [3H]ATPCA is reported as a novel radioactive substrate for both BGT1 and CreaT, and the dual activity of the radioligand makes it most suitable for use in recombinant studies.
Journal ArticleDOI
Identification of Histamine H 3 Receptor Ligands Using a New Crystal Structure Fragment-based Method.
Ida Osborn Frandsen,Michael W. Boesgaard,Kimberley Fidom,Alexander S. Hauser,Vignir Isberg,Hans Bräuner-Osborne,Petrine Wellendorph,David E. Gloriam +7 more
TL;DR: This study provides the first proof-of-concept for the recently reported method where pharmacophores are instead constructed based on the inference of residue-ligand fragments from crystal structures, demonstrating its unique utility for G protein-coupled receptors, which represent the largest families of human membrane proteins and drug targets.
Journal ArticleDOI
Activity of l-α-amino acids at the promiscuous goldfish odorant receptor 5.24
TL;DR: The results show that receptor 5.24 is broadly activated by 19 of the tested l -α-amino acids and displays a preference for basic amino acids.