P
Petrine Wellendorph
Researcher at University of Copenhagen
Publications - 100
Citations - 2883
Petrine Wellendorph is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Receptor & GABAA receptor. The author has an hindex of 27, co-authored 83 publications receiving 2573 citations. Previous affiliations of Petrine Wellendorph include University of Turin & ACADIA Pharmaceuticals Inc..
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Journal ArticleDOI
Pharmacological characterization of mouse GPRC6A, an L‐α‐amino‐acid receptor modulated by divalent cations
Bolette Christiansen,Kasper B. Hansen,Kasper B. Hansen,Petrine Wellendorph,Hans Bräuner-Osborne +4 more
TL;DR: The aim of this study was to develop such an assay and extend the pharmacological characterization of GPRC6A, a novel member of family C of G protein‐coupled receptors with so far unknown function.
Journal ArticleDOI
No evidence for a bone phenotype in GPRC6A knockout mice under normal physiological conditions.
Petrine Wellendorph,Lars Dan Johansen,Anders A. Jensen,Emilio Casanova,Martin Gassmann,Pierre Deprez,Philippe Clément-Lacroix,Bernhard Bettler,Hans Bräuner-Osborne +8 more
TL;DR: The data do not support a role for GPRC6A in normal bone physiology, and assessment of bone mineral density, histomorphometry, and bone metabolism demonstrated no significant differences between 13-week-old knockout and wild-type mice.
Journal ArticleDOI
Delineation of the GPRC6A receptor signaling pathways using a mammalian cell line stably expressing the receptor.
Stine Engesgaard Jacobsen,Lenea Nørskov-Lauritsen,Alex R.B. Thomsen,Sanela Smajilovic,Petrine Wellendorph,Niklas Larsson,Anders Lehmann,Vikram K. Bhatia,Hans Bräuner-Osborne +8 more
TL;DR: It is confirmed that GPRC6A is activated by basic l-α-amino acids and divalent cations, and for the first time, it is conclusively show that these responses are mediated through the Gq pathway.
Journal ArticleDOI
Potency of GABA at human recombinant GABA(A) receptors expressed in Xenopus oocytes: a mini review.
Nasiara Karim,Nasiara Karim,Petrine Wellendorph,Nathan L. Absalom,Graham A.R. Johnston,Jane R. Hanrahan,Mary Chebib +6 more
TL;DR: A systematic characterization of the potency of GABA at 43 human recombinant GABAA receptor combinations expressed in Xenopus oocytes using the two-electrode voltage clamp technique shows that the α-subunits and to a lesser extent, the β-subunit influence GABA potency.
Journal ArticleDOI
The rat GPRC6A: cloning and characterization.
Petrine Wellendorph,Nicole Burhenne,Bolette Christiansen,Bettina Walter,Hartwig Schmale,Hans Bräuner-Osborne +5 more
TL;DR: The presented quantitative pharmacological data underlines the evolutionary conservation of GPRC6A to the rat and signifies the physiological importance and emerging pharmacological potential of G PRC 6A.