P
Philip E. Bourne
Researcher at University of Virginia
Publications - 357
Citations - 64294
Philip E. Bourne is an academic researcher from University of Virginia. The author has contributed to research in topics: Protein Data Bank & Structural genomics. The author has an hindex of 68, co-authored 331 publications receiving 54563 citations. Previous affiliations of Philip E. Bourne include University of Sheffield & University of California, Los Angeles.
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Revealing acquired resistance mechanisms of kinase-targeted drugs using an on-the-fly, function-site interaction fingerprint approach
Zheng Zhao,Philip E. Bourne +1 more
TL;DR: An understanding of the mechanisms of ALK drug resistance is provided, the usefulness of the on-the-fly Fs-IFP approach is confirmed, and a practical paradigm to study drug-resistance mechanisms in prospective drug discovery is provided.
Posted ContentDOI
Systematic Analysis of KRAS-ligand Interaction Modes and Flexibilities Reveals the Binding Characteristics
TL;DR: In this paper , the features of KRAS binding pockets and ligand-binding characteristics of allosteric KRAS complexes using a structural systems pharmacology approach are provided. And the flexibility of the three distinct binding sites to accommodate different potential ligands, based on MD simulation, is discussed.
Journal ArticleDOI
Ten simple rules to aid in achieving a vision.
TL;DR: In a career that now spans 40 years, I have had, on several occasions, opportunities to turn loose ideas into a unified vision and the resources to implement that vision, but all were learnt from.
The Least Difference in Means: A Statistic for Effect Size Strength and Practical Significance
TL;DR: This work proposes the least difference in means (δ L) as a two-sample statistic that can quantify effect strength and perform a hypothesis test to determine if a result has a meaningful effect size.