P
Philip G. Toye
Researcher at International Livestock Research Institute
Publications - 63
Citations - 1706
Philip G. Toye is an academic researcher from International Livestock Research Institute. The author has contributed to research in topics: Theileria parva & East Coast fever. The author has an hindex of 27, co-authored 62 publications receiving 1552 citations.
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Journal ArticleDOI
An enzyme-linked immunosorbent assay for detection of Theileria parva antibodies in cattle using a recombinant polymorphic immunodominant molecule
J.M. Katende,Subhash Morzaria,Philip G. Toye,Robert A. Skilton,Vish Nene,Catherine Nkonge,Antony Musoke +6 more
TL;DR: Evaluation of the PIM-ELISA using experimental sera derived from cattle infected with different hemoparasites and field sera from endemic and nonendemic T. parva areas showed that the assay had a sensitivity of >99% and a specificity of between 94% and 98%.
Journal Article
Strain specificity of bovine Theileria parva-specific cytotoxic T cells is determined by the phenotype of the restricting class I MHC.
TL;DR: Differences in the strain specificities of CTL derived from animals immunized with the same parasite stock, are determined by the class I MHC phenotype of the immunized animal.
Journal ArticleDOI
Two Theileria parva CD8 T cell antigen genes are more variable in buffalo than cattle parasites, but differ in pattern of sequence diversity.
Roger Pelle,Simon P. Graham,Moses N. Njahira,Julius Osaso,Rosemary Saya,David Odongo,Philip G. Toye,P.R. Spooner,Anthony J. Musoke,Duncan Mwangi,Evans L. N. Taracha,W. Ivan Morrison,William Weir,Joana C. Silva,Richard P. Bishop +14 more
TL;DR: The results indicate that T.Parva parasites maintained in cattle represent a subset of the overall T. parva population, which has become adapted for tick transmission between cattle.
Journal Article
Transfection into mouse L cells of genes encoding two serologically and functionally distinct bovine class I MHC molecules from a MHC-homozygous animal
TL;DR: Results demonstrate that the w10 and KN104 specificities are on distinct class I molecules, and provide strong evidence that there are at least two classical class I loci in cattle.
Journal ArticleDOI
Identification of expressed bovine class I MHC genes at two loci and demonstration of physical linkage.
Albert Bensaid,Anita Kaushal,Cynthia L. Baldwin,Hans Clevers,John R. Young,Stephen J. Kemp,Niall D. MacHugh,Philip G. Toye,Alan J. Teale +8 more
TL;DR: A cDNA library prepared from lymphocytes of a cow, homozygous at major histocompatibility complex (MHC) loci (BoLA phenotype w10, KN104), was screened with a bovine MHC class I probe and revealed that the BoLA-w10 and KN104 genes are separated by not more than 210 kilobases and that they are components of a multigene family spanning 1550 kb.