P
Philip J. Spevak
Researcher at Johns Hopkins University
Publications - 69
Citations - 7163
Philip J. Spevak is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Aortic valve & Arrhythmogenic right ventricular dysplasia. The author has an hindex of 39, co-authored 69 publications receiving 6733 citations. Previous affiliations of Philip J. Spevak include Boston Children's Hospital & Harvard University.
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A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2
Bart Loeys,Junji Chen,Enid Neptune,Daniel P. Judge,Megan Podowski,Tammy M. Holm,Jennifer Meyers,Carmen C. Leitch,Nicholas Katsanis,Neda A. Sharifi,F Lauren Xu,Loretha Myers,Philip J. Spevak,Duke E. Cameron,Julie De Backer,Jan Hellemans,Yan Chen,Elaine C. Davis,Catherine L. Webb,Wolfram Kress,Paul Coucke,Daniel B. Rifkin,Anne De Paepe,Harry C. Dietz +23 more
TL;DR: These data definitively implicate perturbation of TGFβ signaling in many common human phenotypes, including craniosynostosis, cleft palate, arterial aneurysms, congenital heart disease and mental retardation, and suggest that comprehensive mechanistic insight will require consideration of both primary and compensatory events.
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Arrhythmogenic Right Ventricular Dysplasia A United States Experience
Darshan Dalal,Khurram Nasir,Chandra Bomma,Kalpana Prakasa,Harikrishna Tandri,Jonathan P. Piccini,Ariel Roguin,Crystal Tichnell,Cynthia A. James,Stuart D. Russell,Daniel P. Judge,Theodore P. Abraham,Philip J. Spevak,David A. Bluemke,Hugh Calkins +14 more
TL;DR: There is a wide variation in presentation and course of ARVD patients, which can likely be explained by the genetic heterogeneity of the disease.
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American society of echocardiography guidelines and standards for performance of the fetal echocardiogram
Jack Rychik,Nancy A. Ayres,Bettina F. Cuneo,Nina L. Gotteiner,Lisa K. Hornberger,Philip J. Spevak,Mary Van Der Veld +6 more
TL;DR: Improved operator skill amongst physicians performing general antepartum obstetrical ultrasound, in combination with increased sensitivity of present day ultrasound systems, has resulted in improved detection of fetal cardiovascular abnormalities and increased requirements for more detailed evaluation.
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Hepatic venous blood and the development of pulmonary arteriovenous malformations in congenital heart disease
Deepak Srivastava,Tamar J. Preminger,James E. Lock,Valerie S. Mandell,John F. Keane,John E. Mayer,Harry P.W. Kozakewich,Philip J. Spevak +7 more
TL;DR: It is postulate that PAVMs after CVPA are related to the diversion of normal hepatic venous flow from the pulmonary circulation, and may be analogous to those associated with liver disease, which have been found to resolve after liver transplantation.
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Double-umbrella closure of atrial defects. Initial clinical applications.
TL;DR: An initial success indicates that double-umbrella closure of atrial septal defects will aid in the treatment of intracardiac defects.