E
Enid Neptune
Researcher at Johns Hopkins University
Publications - 73
Citations - 6249
Enid Neptune is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: COPD & Marfan syndrome. The author has an hindex of 22, co-authored 66 publications receiving 5482 citations. Previous affiliations of Enid Neptune include Johns Hopkins University School of Medicine & University of Minnesota.
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Journal ArticleDOI
Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome.
Jennifer P Habashi,Daniel P. Judge,Tammy M. Holm,Ronald D. Cohn,Bart Loeys,Timothy K. Cooper,Loretha Myers,Erin C Klein,Guosheng Liu,Carla L. Calvi,Megan Podowski,Enid Neptune,Marc K. Halushka,Djahida Bedja,Kathleen L. Gabrielson,Daniel B. Rifkin,Luca Carta,Francesco Ramirez,David L. Huso,Harry C. Dietz +19 more
TL;DR: Losartan, a drug already in clinical use for hypertension, merits investigation as a therapeutic strategy for patients with Marfan syndrome and has the potential to prevent the major life-threatening manifestation of this disorder.
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A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2
Bart Loeys,Junji Chen,Enid Neptune,Daniel P. Judge,Megan Podowski,Tammy M. Holm,Jennifer Meyers,Carmen C. Leitch,Nicholas Katsanis,Neda A. Sharifi,F Lauren Xu,Loretha Myers,Philip J. Spevak,Duke E. Cameron,Julie De Backer,Jan Hellemans,Yan Chen,Elaine C. Davis,Catherine L. Webb,Wolfram Kress,Paul Coucke,Daniel B. Rifkin,Anne De Paepe,Harry C. Dietz +23 more
TL;DR: These data definitively implicate perturbation of TGFβ signaling in many common human phenotypes, including craniosynostosis, cleft palate, arterial aneurysms, congenital heart disease and mental retardation, and suggest that comprehensive mechanistic insight will require consideration of both primary and compensatory events.
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Dysregulation of TGF-β activation contributes to pathogenesis in Marfan syndrome
Enid Neptune,Pamela A. Frischmeyer,Dan E. Arking,Loretha Myers,Tracie E. Bunton,Barbara Gayraud,Francesco Ramirez,Lynn Y. Sakai,Harry C. Dietz +8 more
TL;DR: It is shown that mice deficient in fibrillin-1 have marked dysregulation of transforming growth factor-β (TGF-β) activation and signaling, resulting in apoptosis in the developing lung, and that perturbation of this function can contribute to the pathogenesis of disease.
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Extracellular matrix in lung development, homeostasis and disease
Yong Zhou,Jeffrey C. Horowitz,Alexandra Naba,Namasivayam Ambalavanan,Kamran Atabai,Jenna L. Balestrini,Peter B. Bitterman,Richard A. Corley,Bi-Sen Ding,Adam J. Engler,Kirk C. Hansen,James S. Hagood,Farrah Kheradmand,Qing S. Lin,Enid Neptune,Laura E. Niklason,Luis A. Ortiz,William C. Parks,Daniel J. Tschumperlin,Eric S. White,Harold A. Chapman,Victor J. Thannickal +21 more
TL;DR: This review assesses the current state of lung ECM biology, including fundamental advances in ECM composition, dynamics, topography, and biomechanics; the role of the ECM in normal and aberrant lung development, adult lung diseases and autoimmunity; andECM in the regulation of the stem cell niche.
Journal ArticleDOI
Role of the TGF-β/Alk5 Signaling Pathway in Monocrotaline-induced Pulmonary Hypertension
Ari L. Zaiman,Megan Podowski,Satya Medicherla,Kimberley Gordy,Fang Xu,Lijie Zhen,Larissa A. Shimoda,Enid Neptune,Linda S. Higgins,Alison Murphy,Sarvajit Chakravarty,Andrew A. Protter,Pravin B. Sehgal,Hunter C. Champion,Rubin M. Tuder +14 more
TL;DR: Evidence is provided that increased TGF-beta signaling participates in the pathogenesis of experimental severe PH, with a small but significant improvement in hemodynamic parameters and medial remodeling.