H
Harry P.W. Kozakewich
Researcher at Boston Children's Hospital
Publications - 190
Citations - 13727
Harry P.W. Kozakewich is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Hemangioma & Vascular anomaly. The author has an hindex of 62, co-authored 187 publications receiving 12437 citations. Previous affiliations of Harry P.W. Kozakewich include Brigham and Women's Hospital & Memorial Sloan Kettering Cancer Center.
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Journal ArticleDOI
Cellular markers that distinguish the phases of hemangioma during infancy and childhood.
Kazue Takahashi,John B. Mulliken,Harry P.W. Kozakewich,R. A. Rogers,Judah Folkman,R. A. B. Ezekowitz +5 more
TL;DR: The results provide an objective basis for staging hemangiomas and may be used to evaluate pharmacological agents, such as corticosteroids and interferon alfa-2a, which accelerate regression of hemang iomas.
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Severe hypothyroidism caused by type 3 iodothyronine deiodinase in infantile hemangiomas.
Stephen A. Huang,H. M. Tu,John W. Harney,M. Venihaki,Atul J. Butte,Harry P.W. Kozakewich,Steven J. Fishman,P. R. Larsen +7 more
TL;DR: A three-month-old infant with massive hepatic hemangiomas and primary hypothyroidism who needed very high doses of thyroid hormone to restore euthyroidism and normal thyrotropin secretion was treated, and high levels of type 3 iodothyronine deiodinase activity in the Hemangioma tissue were identified.
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Central giant cell lesions of the jaws: a clinicopathologic study.
TL;DR: Histologic differences between the two groups of aggressive and nonaggressive lesions were not as clear as the differences in biologic behavior, however, aggressive lesions had a higher RSI, and recurrent giant cells lesionsHad a higherRSI and FSA; these parameters warrant further study.
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Somatic Mosaic Activating Mutations in PIK3CA Cause CLOVES Syndrome
Kyle C. Kurek,Valerie L. Luks,Ugur M. Ayturk,Ugur M. Ayturk,Ahmad I. Alomari,Steven J. Fishman,Samantha A. Spencer,John B. Mulliken,Margot E. Bowen,Margot E. Bowen,Guilherme L. Yamamoto,Harry P.W. Kozakewich,Matthew L. Warman +12 more
TL;DR: It is concluded that CLOVES is caused by postzygotic activating mutations in PIK3CA, which have been identified in cancer cells, in which they increase phosphoinositide-3-kinase activity.
Journal ArticleDOI
Lymphatic and Other Vascular Malformative/Overgrowth Disorders Are Caused by Somatic Mutations in PIK3CA
Valerie L. Luks,Nolan Kamitaki,Matthew P. Vivero,Wibke Uller,Rashed Rab,Judith V.M.G. Bovée,Kristy L. Rialon,Carlos J. Guevara,Ahmad I. Alomari,Arin K. Greene,Steven J. Fishman,Harry P.W. Kozakewich,Reid A. Maclellan,John B. Mulliken,Reza Rahbar,Samantha A. Spencer,Cameron C. Trenor,Joseph Upton,David Zurakowski,Jonathan A. Perkins,Andrew L Kirsh,James T. Bennett,William B. Dobyns,Kyle C. Kurek,Matthew L. Warman,Matthew L. Warman,Matthew L. Warman,Steven A. McCarroll,Rudy Murillo +28 more
TL;DR: Most individuals from Boston Children's Hospital who had isolated LM or LM as part of a syndrome were somatic mosaic for PIK3CA mutations, with 5 specific PIK 3CA mutations accounting for ∼ 80% of cases.