P
Philip Reyes
Researcher at University of New Mexico
Publications - 16
Citations - 563
Philip Reyes is an academic researcher from University of New Mexico. The author has contributed to research in topics: Purine & Purine metabolism. The author has an hindex of 11, co-authored 16 publications receiving 557 citations.
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Journal ArticleDOI
Enzymes of purine and pyrimidine metabolism from the human malaria parasite, Plasmodium falciparum.
Philip Reyes,Pradipsinh K. Rathod,Donald J. Sanchez,John E. K. Mrema,Karl H. Rieckmann,Hans-G. Heidrich,Hans-G. Heidrich +6 more
TL;DR: Two enzymes involved in the de novo synthesis of pyrimidines, orotic acid PRTase, and orotidine 5'-phosphate decarboxylase, were present in parasite extracts as were the enzymes for pyrimidine nucleotide phosphorylation.
Journal ArticleDOI
In vitro susceptibilities of Plasmodium falciparum to compounds which inhibit nucleotide metabolism.
TL;DR: Two of the compounds which effectively inhibited parasite growth were found to be potent competitive inhibitors of a key purine-salvaging enzyme (hypoxanthine-guanine-xanthine phosphoribosyltransferase) of the parasite.
Journal ArticleDOI
Properties and substrate specificity of a purine phosphoribosyltransferase from the human malaria parasite, Plasmodium falciparum.
TL;DR: Results support the view that the phosphoribosyltransferase is capable of utilizing all three purine bases as substrates, and that the parasite enzyme might prove to be selectively susceptible to inhibition by xanthine analogs and related compounds.
Journal ArticleDOI
Isolation of intracellular parasites (Plasmodium falciparum) from culture using free-flow electrophoresis: separation of the free parasites according to stages.
TL;DR: Most of the fractions containing free parasites did not show contamination with erythrocyte constituents as determined by light and electron microscopy, polyacrylamide gel electrophoresis, and enzymatic analysis, but the various stages of free parasites of Plasmodium falciparum exhibited different electrical surface charges.
(plasmodium falciparum) from culture using free-flow electrophoresis: separation of the free parasites according to stages
TL;DR: In this paper, a mixture of liberated, free parasites, intact erythrocytes and erythyte membrane vesicles was separated using free-flow electrophoresis.