P
Philipp Arnold
Researcher at University of Erlangen-Nuremberg
Publications - 78
Citations - 1266
Philipp Arnold is an academic researcher from University of Erlangen-Nuremberg. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 15, co-authored 63 publications receiving 778 citations. Previous affiliations of Philipp Arnold include University of Kiel & University of Mainz.
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Journal ArticleDOI
Metalloproteases meprin α and meprin β are C- and N-procollagen proteinases important for collagen assembly and tensile strength
Claudia Broder,Philipp Arnold,Sandrine Vadon-Le Goff,Moritz A. Konerding,Kerstin Bahr,Stefan Müller,Christopher M. Overall,Judith S. Bond,Tomas Koudelka,Andreas Tholey,David J.S. Hulmes,Catherine Moali,Christoph Becker-Pauly +12 more
TL;DR: Meprin α and meprin β are unique in their ability to process and release both C- and N-propeptides from type I procollagen in vitro and in vivo and contribute to the integrity of connective tissue in skin, with consequent implications for inherited connective tissues disorders.
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Meprin α and meprin β: Procollagen proteinases in health and disease
TL;DR: Regulation of meprin activity by specific inhibition to reduce collagen maturation might be a suitable approach for the treatment of certain pathological conditions.
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ADAM17 is required for EGF-R–induced intestinal tumors via IL-6 trans-signaling
Stefanie Schmidt,Neele Schumacher,Jeanette Schwarz,Simone Tangermann,Lukas Kenner,Michaela Schlederer,Maria Sibilia,Markus Linder,Annelore Altendorf-Hofmann,Thomas Knösel,Elisabeth S. Gruber,Georg Oberhuber,Julia Bolik,Ateequr Rehman,Anupam Sinha,Juliane Lokau,Philipp Arnold,Anne-Sophie Cabron,Friederike Zunke,Christoph Becker-Pauly,Adele Preaudet,Paul M Nguyen,Paul M Nguyen,Jennifer Huynh,Shoukat Afshar-Sterle,Ashwini L. Chand,Jürgen Westermann,Peter J. Dempsey,Christoph Garbers,Dirk Schmidt-Arras,Philip Rosenstiel,Tracy L Putoczki,Tracy L Putoczki,Matthias Ernst,Stefan Rose-John +34 more
TL;DR: The data reveal the possibility of a novel strategy for treatment of colorectal cancer that could circumvent intrinsic and acquired resistance to EGF-R blockade and down-regulation of STAT3 and Wnt pathway components.
Journal ArticleDOI
Meprin Metalloproteases Generate Biologically Active Soluble Interleukin-6 Receptor to Induce Trans-Signaling.
Philipp Arnold,Inga Boll,Michelle Rothaug,Neele Schumacher,Frederike Schmidt,Rielana Wichert,Janna Schneppenheim,Juliane Lokau,Ute Pickhinke,Tomas Koudelka,Andreas Tholey,Björn Rabe,Jürgen Scheller,Ralph Lucius,Christoph Garbers,Stefan Rose-John,Christoph Becker-Pauly +16 more
TL;DR: It is demonstrated that the IL-6R is a shedding substrate of soluble meprin α and membrane bound mePRin β, resulting in bioactive sIL- 6R that is capable of inducing IL- 6 trans-signaling.
Journal ArticleDOI
Characterization of the complex formed by β-glucocerebrosidase and the lysosomal integral membrane protein type-2
Friederike Zunke,Lisa Andresen,Sophia Wesseler,Johann Groth,Philipp Arnold,Michelle Rothaug,Joseph R. Mazzulli,Dimitri Krainc,Judith Blanz,Paul Saftig,Michael Schwake +10 more
TL;DR: It is shown that a LIMP-2–derived helical peptide can be used for efficient purification and activation of recombinant and endogenous GC and provides a molecular framework for the design of GC activators as potential treatments in Parkinson’s disease and related synucleinopathies.