M
Michelle Rothaug
Researcher at University of Kiel
Publications - 8
Citations - 615
Michelle Rothaug is an academic researcher from University of Kiel. The author has contributed to research in topics: Proteases & Neurodegeneration. The author has an hindex of 8, co-authored 8 publications receiving 443 citations.
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Journal ArticleDOI
The role of interleukin-6 signaling in nervous tissue.
TL;DR: A modified, recombinant dimerized version of sgp130 (sgp130Fc) has successfully been used to block inflammatory processes in mice and may also be used in the clarification of IL-6 trans-signaling in neurological diseases.
Journal ArticleDOI
LIMP-2 expression is critical for β-glucocerebrosidase activity and α-synuclein clearance.
Michelle Rothaug,Friederike Zunke,Joseph R. Mazzulli,Michaela Schweizer,Hermann C. Altmeppen,Renate Lüllmann-Rauch,Wouter W. Kallemeijn,Paulo Gaspar,Johannes M. F. G. Aerts,Markus Glatzel,Paul Saftig,Dimitri Krainc,Michael Schwake,Judith Blanz +13 more
TL;DR: It is suggested that manipulating LIMP-2 expression to increase lysosomal GC activity is a promising strategy for the treatment of synucleinopathies.
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LAMP-2 deficiency leads to hippocampal dysfunction but normal clearance of neuronal substrates of chaperone-mediated autophagy in a mouse model for Danon disease
Michelle Rothaug,Stijn Stroobants,Michaela Schweizer,Judith Peters,Friederike Zunke,Mirka Allerding,Rudi D'Hooge,Paul Saftig,Judith Blanz +8 more
TL;DR: Data from knockout mice analyzed for neuropathological changes, MA and steady-state levels of CMA substrates contribute to the understanding of intellectual dysfunction observed in Danon disease patients and highlight the role of LAMP-2 within the central nervous system, particularly the hippocampus.
Journal ArticleDOI
Meprin Metalloproteases Generate Biologically Active Soluble Interleukin-6 Receptor to Induce Trans-Signaling.
Philipp Arnold,Inga Boll,Michelle Rothaug,Neele Schumacher,Frederike Schmidt,Rielana Wichert,Janna Schneppenheim,Juliane Lokau,Ute Pickhinke,Tomas Koudelka,Andreas Tholey,Björn Rabe,Jürgen Scheller,Ralph Lucius,Christoph Garbers,Stefan Rose-John,Christoph Becker-Pauly +16 more
TL;DR: It is demonstrated that the IL-6R is a shedding substrate of soluble meprin α and membrane bound mePRin β, resulting in bioactive sIL- 6R that is capable of inducing IL- 6 trans-signaling.
Journal ArticleDOI
Characterization of the complex formed by β-glucocerebrosidase and the lysosomal integral membrane protein type-2
Friederike Zunke,Lisa Andresen,Sophia Wesseler,Johann Groth,Philipp Arnold,Michelle Rothaug,Joseph R. Mazzulli,Dimitri Krainc,Judith Blanz,Paul Saftig,Michael Schwake +10 more
TL;DR: It is shown that a LIMP-2–derived helical peptide can be used for efficient purification and activation of recombinant and endogenous GC and provides a molecular framework for the design of GC activators as potential treatments in Parkinson’s disease and related synucleinopathies.