Philippe Lefebvre

TL;DR: Results show that loss of auditory neurons that occurs subsequent to a Loss of auditory hair cells can be prevented by in vivo neurotrophin therapy with either NT-3 or BDNF.

TL;DR: The results show that there is a modification of cortical and subcortical functional connectivity in tinnitus encompassing attentional, mnemonic, and emotional networks and suggest that various regions of the brain seem involved in the persistent awareness of the phenomenon as well as in the development of the associated distress leading to disabling chronic tinnitis.

TL;DR: Several approaches for the prevention of auditory sensory loss from reactive oxygen species‐induced apoptosis are presented, including preventing the formation of reactive oxygenspecies; neutralizing the toxic products of membrane lipid peroxidation; and blocking the damaged sensory cells’ apoptotic pathway.

TL;DR: A modified functional connectivity pattern in tinnitus sufferers is shown and the role of the parahippocampal region in t Finnitus physiopathology is highlighted, pointing out the importance of the activity and connectivity pattern of the posterior cingulate cortex/precuneus region to the development of theTinnitus associated distress.

TL;DR: It is demonstrated that in patients with AIED, transtympanic delivery of the TNF-α blocker infliximab once weekly for 4 weeks allowed steroids to be tapered off, resulted in hearing improvement and reduced disease relapses.