P
Piero Pignataro
Researcher at University of Naples Federico II
Publications - 18
Citations - 397
Piero Pignataro is an academic researcher from University of Naples Federico II. The author has contributed to research in topics: Single-nucleotide polymorphism & Genome-wide association study. The author has an hindex of 8, co-authored 18 publications receiving 290 citations.
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Journal ArticleDOI
Multi-gene panel testing improves diagnosis and management of patients with hereditary anemias.
Roberta Russo,Immacolata Andolfo,Francesco Manna,Antonella Gambale,Roberta Marra,Barbara Eleni Rosato,Paola Caforio,Valeria Pinto,Piero Pignataro,Kottayam Radhakrishnan,Sule Unal,Giovanna Tomaiuolo,Gian Luca Forni,Achille Iolascon +13 more
TL;DR: A patient showing marked iron overload due to the coinheritance of PIEZO1 and SEC23B mutations is described, demonstrating that the multi‐gene approach is valuable not only for achieving a correct and definitive diagnosis, but also for guiding treatment.
Journal ArticleDOI
Exome and deep sequencing of clinically aggressive neuroblastoma reveal somatic mutations that affect key pathways involved in cancer progression.
Vito Alessandro Lasorsa,Daniela Formicola,Piero Pignataro,Flora Cimmino,Francesco Maria Calabrese,Jaume Mora,Maria Rosaria Esposito,Marcella Pantile,Carlo Zanon,Marilena De Mariano,Luca Longo,Michael D. Hogarty,Carmen Torres,Gian Paolo Tonini,Achille Iolascon,Mario Capasso +15 more
TL;DR: The analyses show pathway-level implications of infrequently mutated genes in leading neuroblastoma progression, and Notably BARD1, CHEK2 and AXIN2 were enriched in rare, potentially pathogenic, germline variants.
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Fine mapping of 2q35 high‐risk neuroblastoma locus reveals independent functional risk variants and suggests full‐length BARD1 as tumor‐suppressor
Flora Cimmino,Marianna Avitabile,Sharon J. Diskin,Sharon J. Diskin,Zalman Vaksman,Zalman Vaksman,Piero Pignataro,Daniela Formicola,Antonella Cardinale,Alessandro Testori,Jan Koster,Carmen Torres,Marcella Devoto,Marcella Devoto,John M. Maris,John M. Maris,Achille Iolascon,Mario Capasso +17 more
TL;DR: A previous genome‐wide association study (GWAS) identified common variation at the BARD1 locus as being highly associated with susceptibility to high‐risk neuroblastoma, but the mechanisms underlying this association have been not extensively investigated.
Journal ArticleDOI
An 18 gene expression‑based score classifier predicts the clinical outcome in stage 4 neuroblastoma
Daniela Formicola,Giuseppe Petrosino,Vito Alessandro Lasorsa,Piero Pignataro,Flora Cimmino,Simona Vetrella,Luca Longo,Gian Paolo Tonini,André Oberthuer,Achille Iolascon,Matthias Fischer,Matthias Fischer,Mario Capasso +12 more
TL;DR: Using microarray analyses of 342 primary tumors, the authors developed and validated an easy to use gene expression-based risk score including 18 genes, which can robustly predict the outcome of stage 4 patients.
An 18 gene expression-based score classifier predicts the clinical outcome in stage 4
Giuseppe Petrosino,Vito Alessandro Lasorsa,Piero Pignataro,Flora Cimmino,Simona Vetrella,Luca Longo,Gian Paolo Tonini,André Oberthuer,Achille Iolascon,Matthias Fischer,Mario Capasso +10 more
TL;DR: Together, the 18-gene risk score classifier can identify patients with stage 4 NB with favorable outcome and may therefore improve risk assessment and treatment stratification of NB patients with disseminated disease.