L
Luca Longo
Researcher at National Cancer Research Institute
Publications - 47
Citations - 2677
Luca Longo is an academic researcher from National Cancer Research Institute. The author has contributed to research in topics: Neuroblastoma & Familial Neuroblastoma. The author has an hindex of 21, co-authored 45 publications receiving 2293 citations. Previous affiliations of Luca Longo include University of Genoa & University of Geneva.
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Journal ArticleDOI
Identification of ALK as a major familial neuroblastoma predisposition gene
Yael P. Mosse,Marci Laudenslager,Luca Longo,Kristina A. Cole,Andrew C. Wood,Edward F. Attiyeh,Michael J. Laquaglia,Rachel Sennett,Jill E. Lynch,Patrizia Perri,Genevieve Laureys,Frank Speleman,Cecilia Kim,Cuiping Hou,Cuiping Hou,Hakon Hakonarson,Hakon Hakonarson,Ali Torkamani,Nicholas J. Schork,Garrett M. Brodeur,Gian Paolo Tonini,Eric F. Rappaport,Marcella Devoto,Marcella Devoto,John M. Maris +24 more
TL;DR: It is demonstrated that heritable mutations of ALK are the main cause of familial neuroblastoma, and that germline or acquired activation of this cell-surface kinase is a tractable therapeutic target for this lethal paediatric malignancy.
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Mutation-independent anaplastic lymphoma kinase overexpression in poor prognosis neuroblastoma patients.
Lorena Passoni,Luca Longo,Paola Collini,Addolorata Coluccia,Fabio Bozzi,Marta Podda,Andrea Gregorio,Claudio Gambini,Alberto Garaventa,Vito Pistoia,Federica Grosso,Gian Paolo Tonini,Mangeng Cheng,Carlo Gambacorti-Passerini,Andrea Anichini,Franca Fossati-Bellani,Massimo Di Nicola,Roberto Luksch +17 more
TL;DR: Interestingly, protein levels did not always correlate with ALK genetic alterations and/or mRNA abundance, however, wild-type ALK receptor requires a critical threshold of expression to achieve oncogenic activation.
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Replication of GWAS-identified neuroblastoma risk loci strengthens the role of BARD1 and affirms the cumulative effect of genetic variations on disease susceptibility.
Mario Capasso,Sharon J. Diskin,Francesca Totaro,Luca Longo,Marilena De Mariano,Roberta Russo,Flora Cimmino,Hakon Hakonarson,Hakon Hakonarson,Gian Paolo Tonini,Marcella Devoto,Marcella Devoto,John M. Maris,Achille Iolascon +13 more
TL;DR: This study shows that even in the absence of interaction the combination of several low-penetrance alleles has potential to distinguish subgroups of patients at different risks of developing NB.
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Liquid Biopsy in Non-Small Cell Lung Cancer: Highlights and Challenges.
TL;DR: In this regard, liquid biopsy represents a minimally invasive and more comprehensive option for early detection and investigation of this tumor.
Journal ArticleDOI
Combined Therapeutic Effects of Vinblastine and Rapamycin on Human Neuroblastoma Growth, Apoptosis, and Angiogenesis
Danilo Marimpietri,Chiara Brignole,Beatrice Nico,Fabio Pastorino,Annalisa Pezzolo,Federica Piccardi,Michele Cilli,Daniela Di Paolo,Gabriella Pagnan,Luca Longo,Patrizia Perri,Domenico Ribatti,Mirco Ponzoni +12 more
TL;DR: Histologic evaluation of primary tumors showed that the combined treatment inhibited proliferation and angiogenesis and induced apoptosis and the therapeutic effectiveness was statistically improved by the combined therapy, compared with mice treated with either drug tested separately.