P
Pierre C. Dagher
Researcher at Indiana University
Publications - 96
Citations - 4475
Pierre C. Dagher is an academic researcher from Indiana University. The author has contributed to research in topics: Kidney & Acute kidney injury. The author has an hindex of 31, co-authored 94 publications receiving 3716 citations. Previous affiliations of Pierre C. Dagher include United States Department of Veterans Affairs & Veterans Health Administration.
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Journal ArticleDOI
Functional studies of the kidney of living animals using multicolor two-photon microscopy.
Kenneth W. Dunn,Ruben M. Sandoval,Katherine J. Kelly,Pierre C. Dagher,George A. Tanner,Simon J. Atkinson,Robert L. Bacallao,Bruce A. Molitoris +7 more
TL;DR: The studies described here demonstrate the way in which two-photon microscopy can provide a level of resolution previously unattainable in intravital microscopy, enabling kinetic analyses and physiological studies of the organs of living animals with subcellular resolution.
Journal ArticleDOI
siRNA Targeted to p53 Attenuates Ischemic and Cisplatin-Induced Acute Kidney Injury
Bruce A. Molitoris,Pierre C. Dagher,Ruben M. Sandoval,Silvia B. Campos,Hagit Ashush,Eduard Fridman,Anat Brafman,Alexander Faerman,Simon J. Atkinson,James D. Thompson,Hagar Kalinski,Rami Skaliter,Shai Erlich,Elena Feinstein +13 more
TL;DR: Data indicate that rapid delivery of siRNA to proximal tubule cells follows intravenous administration, suggesting potential therapeutic benefit for ischemic and nephrotoxic kidney injury.
Journal ArticleDOI
P53 Mediates the Apoptotic Response to GTP Depletion after Renal Ischemia-Reperfusion: Protective Role of a p53 Inhibitor
TL;DR: It is concluded that p53 is an important mediator of apoptosis during states of GTP depletion and inhibitors of p53 should be considered in the treatment of ischemic renal injury.
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A novel method to determine specificity and sensitivity of the TUNEL reaction in the quantitation of apoptosis
TL;DR: A novel and simple method consisting of staining live cells and tissues with Hoechst 33342 and the vital dye propidium iodide followed by fixation and the TUNEL reaction is developed, which will permit the determination of indices of sensitivity and specificity for the T UNEL assay in other tissues and experimental conditions.
Journal ArticleDOI
Guanosine supplementation reduces apoptosis and protects renal function in the setting of ischemic injury
TL;DR: It is concluded that guanosine protects against renal ischemic injury by replenishing GTP stores and preventing tubular apoptosis.