Elena Feinstein

TL;DR: It is shown that sestrins, a family of proteins whose expression is modulated by p53, are required for regeneration of Prxs containing Cys-SO2H, thus reestablishing the antioxidant firewall.

TL;DR: CBLB502, a polypeptide drug derived from Salmonella flagellin that binds to Toll-like receptor 5 (TLR5) and activates nuclear factor–κB signaling, protected mice from both gastrointestinal and hematopoietic acute radiation syndromes and resulted in improved survival.

TL;DR: The identification and cloning of a novel HIF-1-responsive gene, designated RTP801, and its strong up-regulation by hypoxia was detected both in vitro and in vivo in an animal model of ischemic stroke suggest a complex type of involvement of RTP802 in the pathogenesis of isChemic diseases.

TL;DR: Conditional overexpression of the Hi95 cDNA in MCF7-tet-off cells resulted in their protection against cell death induced by hypoxia/glucose deprivation or H2O2, suggesting Hi95 gene seems to be involved in complex regulation of cell viability in response to different stress conditions.

TL;DR: Data indicate that rapid delivery of siRNA to proximal tubule cells follows intravenous administration, suggesting potential therapeutic benefit for ischemic and nephrotoxic kidney injury.