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Pierre De Meyts
Researcher at Novo Nordisk
Publications - 69
Citations - 6309
Pierre De Meyts is an academic researcher from Novo Nordisk. The author has contributed to research in topics: Insulin receptor & Insulin. The author has an hindex of 34, co-authored 63 publications receiving 5914 citations. Previous affiliations of Pierre De Meyts include Catholic University of Leuven & National Institutes of Health.
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Insulin-Dependent Regulation of Insulin Receptor Concentrations: A Direct Demonstration in Cell Culture
TL;DR: The data suggest a reciprocal relationship between insulin in the extracellular fluid and the concentration of insulin receptors per cell, which is mediated at the target cell itself by intracellular insulin-sensitive regulatory processes and directly affects target-cell sensitivity to hormone.
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Insulin interactions with its receptors: experimental evidence for negative cooperativity.
TL;DR: A simple method is reported to detect cooperative interactions in the binding of polypeptide hormones to their membrane receptors, and Insulin receptors on cultured lymphocytes and liver plasma membranes show negative cooperative interactions.
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Structural biology of insulin and IGF1 receptors: implications for drug design.
TL;DR: Recent progress in understanding the structure–function relationships of the insulin and insulin-like growth factor 1 (IGF1) receptors, their mechanism of activation and their implications for the design of insulin-receptor agonists for diabetes therapy and IGF1-recept antagonists for cancer therapy are discussed.
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Cooperativity in ligand binding: a new graphic analysis.
Pierre De Meyts,Jesse Roth +1 more
TL;DR: A new parameter is proposed, the average affinity of the receptor sites, K, calculated as ( B F/(R o −B) , which has been successfully applied to the negative cooperativity of insulin receptors.
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Insulin and its receptor: structure, function and evolution
TL;DR: In the absence of a full three-dimensional structure of the insulin–receptor complex, the existing pieces of the puzzle generated by insulin chemists and molecular biologists are assembled in order to generate a plausible mechanistic model of the diabetes interaction that explains its kinetics and negative cooperativity.