http://www.farm.ucl.ac.be/Full-texts-FARM/Hoet-2004-2.pdf

Natural products active against African trypanosomes: a step towards new drugs

Yeast and mammalian alpha-glucosidase inhibitory constituents from Himalayan rhubarb Rheum emodi Wall.ex Meisson.

Use of liquid chromatography-electrospray ionization tandem mass spectrometry to identify diarylheptanoids in turmeric (Curcuma longa L.) rhizome.

https://doc.rero.ch/record/11902/files/Tabacchi_Raphael_-_Bafoudiosbulbins_A_and_B_two_anti-salmonellal_20090514.pdf

Bafoudiosbulbins A, and B, two anti-salmonellal clerodane diterpenoids from Dioscorea bulbifera L. var sativa.

Diarylheptanoids, natural products with a 1,7-diphenylheptane structural skeleton, are mainly distributed in the roots, rhizomes and bark of Alpinia, Zingiber, Curcuma and Alnus species They have become of interest in natural product research over the past twenty years because of their remarkable anti-cancer, anti-emetic, estrogenic, anti-microbial and anti-oxidant activity This paper compiles all 307 naturally occurring diarylheptanoids from 46 plants as reported in 137 references with their distributions, physiological activities and 13C-NMR spectral data

https://journals.sagepub.com/doi/pdf/10.1177/1934578X1000501035

Naturally occurring diarylheptanoids.

Three new diarylheptanoids, (4Z,6E)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)hepta-4,6-dien-3-one, letestuianin A (1), (4Z,6E)-5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-4,6-dien-3-one, letestuianin B (2), and 1,7-bis(4-hydroxyphenyl)heptan-3,5-dione, letestuianin C (3), as well as the known (4Z,6E)-5-hydroxy-1,7-bis(4-hydroxyphenyl)hepta-4,6-dien-3-one (5) were isolated from Aframomum letestuianum. The known flavonoids 3-acetoxy-5,7,4'-trihydroxyflavanone, 3-acetoxy-7-methoxy-5,4'-dihydroxyflavanone, 7-methoxy-3,5,4'-trihydroxyflavone, and 3,3',4',5,7-pentahydroxyflavan were also obtained from this plant. Their structures were determined using a combination of 1D and 2D NMR techniques. The four diarylheptanoids were tested for growth inhibitory activity in vitro versus bloodstream forms of African trypanosomes. IC(50) values in the range of 1-3 microg/mL were found for compounds 3 and 5.

Trypanocidal diarylheptanoids from Aframomum letestuianum.

Diarylheptanoids from Myrica arborea.

Antimicrobial-guided fractionation of the EtOAc extract of the stem bark of Croton macrostachys afforded five known compounds including two lupane triterpenoids, lupeol (1) and betulin (2), and three clerodane diterpenoids, floridolide A (3), hardwickic acid (4) and 12-oxo-hardwickic acid (5). Their structures were elucidated on the basis of spectral studies and comparison with published data. The EtOAc extract and compounds 1, 2, 4 and 5 were evaluated for their antibacterial and antifungal activities by macro-dilution method. The extract displayed significant antibacterial and antifungal activities (MIC = 31.25-1000 μg/ml). Betulin (2) and 12-oxo-hardwickic acid (5) were the most active compounds (MIC = 7.81-500 μg/ml). The most sensitive microorganisms were Staphylococcus aureus ATCC 25922 for bacteria and two Candida species, Candida albicans ATCC 24433 and Candida krusei ATCC 6258, for fungi. The isolation of these active antibacterial and antifungal principles supports the use of C. macrostachys in traditional medicine for the treatment of microbial infections. Keywords: Croton macrostachys; Euphorbiaceae; triterpenes; diterpenes; antibacterial; antifungal.

/pdf/antimicrobial-diterpenoids-and-triterpenoids-from-the-stem-1oqc6s31wu.pdf

Pierre Tane

Papers

Trypanocidal diarylheptanoids from Aframomum letestuianum.

Diarylheptanoids from Myrica arborea.

Antimicrobial diterpenoids and triterpenoids from the stem bark of Croton macrostachys

Chromone glycosides from Schumanniophyton magnificum

Partially-acetylated dodecanyl tri- and tetra-rhamnoside derivatives from Cleistopholis glauca (Annonaceae)