O
Olov Sterner
Researcher at Lund University
Publications - 529
Citations - 11426
Olov Sterner is an academic researcher from Lund University. The author has contributed to research in topics: GABAA receptor & Magnaporthe grisea. The author has an hindex of 49, co-authored 527 publications receiving 10630 citations. Previous affiliations of Olov Sterner include Autonomous University of Campeche & University of Yaoundé.
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Journal ArticleDOI
Pungent products from garlic activate the sensory ion channel TRPA1
Diana M. Bautista,Pouya Movahed,Andrew Hinman,Helena E. Axelsson,Olov Sterner,Edward D. Högestätt,David Julius,Sven-Eric Jordt,Peter M. Zygmunt +8 more
TL;DR: It is shown that allicin and DADS excite an allyl isothiocyanate-sensitive subpopulation of sensory neurons and induce vasodilation by activating capsaicin-sensitive perivascular sensory nerve endings, suggesting that garlic excites sensory neurons primarily through activation of TRPA1.
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TRPA1 mediates spinal antinociception induced by acetaminophen and the cannabinoid Δ 9 -tetrahydrocannabiorcol
David Andersson,Clive Gentry,Lisa Alenmyr,Dan Killander,Simon E. Lewis,Anders F. Andersson,Bernard Bucher,Jean-Luc Galzi,Olov Sterner,Stuart Bevan,Edward D. Högestätt,Peter M. Zygmunt +11 more
TL;DR: The antinociceptive effects of spinal and systemic administration of acetaminophen are shown to be lost in Trpa1(-/-) mice and spinal TRPA1 activation is disclosed as a potential pharmacological strategy to alleviate pain.
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Endogenous unsaturated C18 N-acylethanolamines are vanilloid receptor (TRPV1) agonists.
Pouya Movahed,Bo A. G. Jönsson,Bryndis Birnir,Johan Wingstrand,Tino Dyhring Jørgensen,Anna Ermund,Olov Sterner,Peter M. Zygmunt,Edward D. Högestätt +8 more
TL;DR: It is shown that several endogenous non-cannabinoid NAEs, many of which are more abundant than anandamide in rat tissues, activate TRPV1 and thus may play a role as endogenous TRPv1 modulators.
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Arzanol, an anti-inflammatory and anti-HIV-1 phloroglucinol alpha-Pyrone from Helichrysum italicum ssp. microphyllum.
Giovanni Appendino,Michela Ottino,Nieves Marquez,Federica Bianchi,Anna Giana,Mauro Ballero,Olov Sterner,Bernd L. Fiebich,Eduardo Muñoz +8 more
TL;DR: Arzanol inhibited HIV-1 replication in T cells and the release of pro-inflammatory cytokines in LPS-stimulated primary monocytes, qualifying as a novel plant-derived anti-inflammatory and antiviral chemotype worth further investigation.
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Assays of the biological activities of guaiane sesquiterpenoids isolated from the fruit bodies of edible lactarius species
TL;DR: Three sesquiterpenoids that are found in the edible mushrooms Lactarius deliciosus, L. deterrimus and L. sanguifluus, have been assayed for biological activity and all three compounds showed weak mutagenic activity in the Ames assay.