Pieter E. S. Smith

TL;DR: A combination of solid-state NMR and differential scanning calorimetry experiments shows curcumin has a strong effect on membrane structure at low concentrations, and shows promise for understanding the action of other drugs such as capsaicin in which drug-induced alterations of membrane structure have strong pharmacological effects.

TL;DR: Results indicate IAPP may induce the formation of pores by the induction of excess membrane curvature and can be used to guide the design of compounds that can prevent the cell-toxicity of IAPP.

TL;DR: Results show that the amphipathic dendrimer molecule can be stably incorporated in the interior of the bilayer (as opposed to electrostatic binding at the surface), and are expected to be useful in the design of d endrimer-based nanobiotechnologies.

TL;DR: This study presents an approach that combines NMR with computational methods to elucidate the structural conformations of Htt Exon 1 in solution and indicates that low-pH protonation stabilizes a soluble conformation where a helical region of N17 propagates into the polyQ region, while at neutral pH both N17 and the poly Q become largely unstructured-thereby suggesting a mechanism for how N17 regulates Htt aggregation.

TL;DR: High Magnetic Fields Proceedings of the International Conference held at the Massachusetts Institute of Technology, Cambridge, Massachusetts, November 1-4, 1961 Edited by Henry Kolm, Benjamin Lax, Francis Bitter and Robert Mills Pp xv + 751.