Pieter-Jan Stiers

TL;DR: It is shown that obstruction of vascular invasion during bone healing favours chondrogenic over osteogenic differentiation of skeletal progenitor cells, driven by a decreased availability of extracellular lipids.

TL;DR: Lipid availability determines fate of skeletal progenitor cells via SOX9 and its role in cell reprograming is revealed.

TL;DR: Angiogenic dependent and independent processes may counteract the deleterious hypoxic effects and several therapeutic strategies that may be combined to withstand the hypoxia upon implantation and improve bone regeneration are discussed.

TL;DR: The results show that induction of angiogenesis alone may lead to adverse effects during endochondral bone repair, whereas activation of hypoxia signaling represents a superior therapeutic strategy to improve end mitochondral bone regeneration in large tissue‐engineered implants.

TL;DR: An ectopic imaging window that can be placed over a tissue‐engineered construct implanted in mice will facilitate further analysis of the spatiotemporal regulation of cellular processes in bone tissue–engineered implants and provides a powerful tool to enhance the therapeutic potential of bone tissue engineering.