Azeem Sharda

TL;DR: It is shown that obstruction of vascular invasion during bone healing favours chondrogenic over osteogenic differentiation of skeletal progenitor cells, driven by a decreased availability of extracellular lipids.

TL;DR: A biomaterial-based scaffold that mimics features of T cell lymphopoiesis in the bone marrow improves T cell regeneration after hematopoietic stem cell transplantation and may provide an off-the-shelf approach for enhancing T cell Regeneration and mitigating graft-versus-host disease in HSCT.

TL;DR: It is shown that a macroporous-biomaterial vaccine that delivers the cytokine granulocyte–macrophage colony-stimulating factor, the Toll-like-receptor-9 agonist cytosine–guanosine oligodeoxynucleotide and one or multiple leukaemia antigens induces local immune-cell infiltration and activated dendritic cells, evoking a potent anti-AML response.

TL;DR: It is proposed that timed cell-intrinsic or niche-focused metabolic disruption can exploit a transient vulnerability and induce metabolic collapse in cancer cells to overcome chemoresistance.

TL;DR: Inhibiting Aldh3a2 provides a therapeutic opportunity and a unique synthetic lethality to exploit the distinctive metabolic state of malignant cells in acute myeloid leukemia.