G
Geert Carmeliet
Researcher at Katholieke Universiteit Leuven
Publications - 222
Citations - 18681
Geert Carmeliet is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Calcitriol receptor & Vitamin D and neurology. The author has an hindex of 62, co-authored 209 publications receiving 15957 citations.
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Journal ArticleDOI
Vitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice
Roger Bouillon,Geert Carmeliet,Lieve Verlinden,Evelyne van Etten,Annemieke Verstuyf,Hilary F. Luderer,Liesbet Lieben,Chantal Mathieu,Marie B. Demay +8 more
TL;DR: The precise mode of action and the full spectrum of activities of the vitamin D hormone, 1,25-dihydroxyvitamin D [1,25-(OH)(2)D], can now be better evaluated by critical analysis of mice with engineered deletion of the Vitamin D receptor (VDR).
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Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects.
TL;DR: The structure of the liganded VDR/RXR complex was recently characterized using cryoelectron microscopy, X-ray scattering, and hydrogen deuterium exchange, which will result in a more complete understanding of VDR coactivator interactions, thus facilitating cell and gene specific clinical applications.
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Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1
Aernout Luttun,Marc Tjwa,Lieve Moons,Yan Wu,Anne Angelillo-Scherrer,Francesca-Fang Liao,Janice A. Nagy,Andrea T. Hooper,Josef Priller,Bert De Klerck,Bert De Klerck,Veerle Compernolle,Evis Daci,Peter Bohlen,Mieke Dewerchin,Jean Marc Herbert,Roy A. Fava,Patrick Matthys,Patrick Matthys,Geert Carmeliet,Desire Collen,Harold F. Dvorak,Daniel J. Hicklin,Peter Carmeliet +23 more
TL;DR: PlGF stimulated angiogenesis and collateral growth in ischemic heart and limb with at least a comparable efficiency to vascular endothelial growth factor (VEGF) and an antibody against Flt1 suppressed neovascularization in tumors and isChemic retina, and angiogenic and inflammatory joint destruction in autoimmune arthritis.
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Osteoblast Precursors, but Not Mature Osteoblasts, Move into Developing and Fractured Bones along with Invading Blood Vessels
Christa Maes,Tatsuya Kobayashi,Martin K. Selig,Sophie Torrekens,Sanford I. Roth,Susan Mackem,Geert Carmeliet,Henry M. Kronenberg +7 more
TL;DR: Findings reveal the specific involvement of immature osteoblast precursors in the coupled vascular and osteogenic transformation essential to endochondral bone development and repair.
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Skeletal and Extraskeletal Actions of Vitamin D: Current Evidence and Outstanding Questions.
Roger Bouillon,Claudio Marcocci,Geert Carmeliet,Daniel D. Bikle,John H. White,Bess Dawson-Hughes,Paul Lips,Craig F Munns,Craig F Munns,Marise Lazaretti-Castro,Andrea Giustina,John P. Bilezikian +11 more
TL;DR: There is a need for continued ongoing and future basic and clinical studies to better define whether vitamin D status can be optimized to improve many aspects of human health, and what is plausible regarding the health effects of vitamin D.