Johan Swinnen

TL;DR: These findings point toward a central tie between energy, anabolism, and cancer and suggest that the cellular energy sensing machinery in cancer cells is an exploitable target for cancer prevention and/or therapy.

TL;DR: It is shown that obstruction of vascular invasion during bone healing favours chondrogenic over osteogenic differentiation of skeletal progenitor cells, driven by a decreased availability of extracellular lipids.

TL;DR: This work provides mechanistic insight into processes of lipid metabolism that underpin the acquisition of therapy-induced GPX4 dependence and ferroptosis hypersensitivity to standard of care therapies in PCa and demonstrates novel strategies to suppress the therapy-tolerant state.

TL;DR: It is demonstrated that prostate cancer cells are not able to respond to decreased fatty acid degradation, and are instead activated by incomplete autophagy, which is followed by activation of the cell death response.

TL;DR: It is shown that SFAs need to enter the cells and to be activated into acyl-CoA to lead to NLRP3 activation in human macrophages, and this work opens novel therapeutic avenues to interfere with Western diet-associated diseases such as those targeting the glycerolipid pathway.