P
Pieter R. Cullis
Researcher at University of British Columbia
Publications - 472
Citations - 55317
Pieter R. Cullis is an academic researcher from University of British Columbia. The author has contributed to research in topics: Liposome & Vesicle. The author has an hindex of 113, co-authored 458 publications receiving 49522 citations. Previous affiliations of Pieter R. Cullis include Utrecht University & Princeton University.
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Ca2+-induced fusion of phospholipid-vesicles containing free fatty-acids - modulation by transmembrane ph gradients
TL;DR: The kinetics of the fusion process upon simultaneous generation of the pH gradient across the vesicle bilayer and initiation of the Fusion reaction show that the inward movement of oleic acid in response to the pHgradient is extremely fast, occurring well within 1 s.
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Use of a lipid nanoparticle system as a Trojan horse in delivery of gold nanoparticles to human breast cancer cells for improved outcomes in radiation therapy
Kyle Bromma,Kristy Rieck,Jayesh A. Kulkarni,Connor O'Sullivan,Wonmo Sung,Pieter R. Cullis,Jan Schuemann,Devika B. Chithrani,Devika B. Chithrani +8 more
TL;DR: This study shows that the cell cycle, GNPs, and radiation therapy can be combined to improve outcome of cancer therapy and provides a novel lipid-based NP platform to further improve GNP-mediated radiation therapy through synchronization of breast cancer cell population.
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Development and clinical applications of siRNA-encapsulated lipid nanoparticles in cancer
TL;DR: Improvements in LNP technology through development of more potent and biocompatible ionizable cationic lipids along with targeting lipids to mediate delivery of LNPs specifically to cancer cells are on the horizon.
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Ionophore-mediated loading of Ca2+ into large unilamellar vesicles in response to transmembrane pH gradients.
TL;DR: The Ca2+ translocating properties of the carboxylic ionophores A23187, ionomycin and lasolocid A (X537A) have been investigated by employing large unilamellar vesicles that exhibit a pH gradient (acidic interior).
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Acyl chain orientational order in large unilamellar vesicles: comparison with multilamellar liposomes: a 2H and 31P nuclear magnetic resonance study
David B. Fenske,Pieter R. Cullis +1 more
TL;DR: Large unilamellar vesicles (LUVs) composed of 1-[2H31]palmitoyl-2-oleoyl phosphatidylcholine (POPC-d31), with diameters of approximately 117 +/- 31 and 180 +/- 44 nm, were prepared by extrusion through polycarbonate filters with pore sizes of 0.1 and 0.2 microns.