P
Pieter R. Cullis
Researcher at University of British Columbia
Publications - 472
Citations - 55317
Pieter R. Cullis is an academic researcher from University of British Columbia. The author has contributed to research in topics: Liposome & Vesicle. The author has an hindex of 113, co-authored 458 publications receiving 49522 citations. Previous affiliations of Pieter R. Cullis include Utrecht University & Princeton University.
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Book ChapterDOI
Membrane Fusion and Lipid Polymorphism
Arie J. Verkleij,R. Van Venetië,J. Leunissen-Bijvelt,B. de Kruijff,Michael J. Hope,Pieter R. Cullis +5 more
TL;DR: If fusion is stopped at the stage of joining and the two membranes stay connected one may call it arrested fusion, and aqueous compartments, which were separated before the fusion, will intermix.
Journal ArticleDOI
Detection of vesicular lipoproteins in lecithin:cholesterol acyltransferase-deficient plasma by 1H-NMR spectroscopy.
TL;DR: Proton NMR spectra of the N-methyl choline region of normal and lecithin:cholesterol acyltransferase (LCAT)-deficient lipoproteins and of egg yolk phosphatidylcholine-cholesterol 55:45 (mol %) vesicle mixtures have been examined to demonstrate that this technique can be used to detect and quantify small amounts of vesicular structures directly in a mixture of micellar lipoproteinins.
Journal ArticleDOI
Exciting Times for Lipid Nanoparticles: How Canadian Discoveries Are Enabling Gene Therapies.
TL;DR: In this brief perspective, key events in the history of the lipid-based nanomedicine field are described, Canadian contributions are highlighted, and areas where lipid nanoparticle technology is poised to have a transformative effect on the future of medicine are outlined.
Journal ArticleDOI
Clinical and preclinical pharmacology of liposomal vincristine
Murray S. Webb,Andreas H. Sarris,Fernando Cabanillas,Lawrence D. Mayer,Marcel B. Bally,Clive T. R. Burge,Pieter R. Cullis +6 more
TL;DR: It is concluded that liposomal vincristine can be given at high doses, is active and well tolerated and is rarely neurotoxic or myelosuppressive in these heavily pretreated patients.