P
Pieter R. Cullis
Researcher at University of British Columbia
Publications - 472
Citations - 55317
Pieter R. Cullis is an academic researcher from University of British Columbia. The author has contributed to research in topics: Liposome & Vesicle. The author has an hindex of 113, co-authored 458 publications receiving 49522 citations. Previous affiliations of Pieter R. Cullis include Utrecht University & Princeton University.
Papers
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Journal ArticleDOI
A Glu-urea-Lys Ligand-conjugated Lipid Nanoparticle/siRNA System Inhibits Androgen Receptor Expression In Vivo
Justin B. Lee,Kaixin Zhang,Yuen Yi C. Tam,Joslyn Quick,Ying K. Tam,Paulo Jc Lin,Sam Chen,Yan Liu,Jayaprakash K. Nair,Ivan Zlatev,Kallanthottathil G. Rajeev,Muthiah Manoharan,Paul S. Rennie,Pieter R. Cullis +13 more
TL;DR: The potential clinical utility of a prostate-specific membrane antigen–targeted lipid nanoparticle system to silence the androgen receptor in advanced prostate cancer is supported and a lipid nanoparticles system with improved potency and significant therapeutic potential was developed.
Journal ArticleDOI
An immune response to ovalbumin covalently coupled to liposomes is prevented when the liposomes used contain doxorubicin
TL;DR: This study evaluates whether an immune response to a protein, covalently attached to liposomes by a thioether bond between N-succinimidyl-3-(2-pyridyldithio)propionate (SPDP)-modified-protein and N-4-(P-maleimidophenyl)butyryl)-activated lipids, can be suppressed when the liposome used contain the anti-cancer drug doxorubicin
Journal ArticleDOI
Incorporation of amphotericin B into large unilamellar vesicles composed of phosphatidylcholine and phosphatidylglycerol.
TL;DR: The spontaneous incorporation of the polyene antibiotic amphotericin B from a micellar solution into phospholipid vesicles was examined as a function of the lipid composition of the vesicle and their physical state to determine their relative bilayer stabilities.
Book ChapterDOI
"Diffusible-PEG-lipid stabilized plasmid lipid particles".
Ian MacLachlan,Pieter R. Cullis +1 more
TL;DR: This work compares the detergent dialysis method ofSPLP manufacture with an alternative method, spontaneous vesicle formation by ethanol dilution, and the pharmacology of SPLP, as determined by monitoring lipid label and quantitative real time PCR.
Journal ArticleDOI
Influence of vesicle size on complement-dependent immune damage to liposomes
Roberta L. Richards,Robert C. Habbersett,Irwin Scher,Andrew S. Janoff,Hugh P. Schieren,Lawrence D. Mayer,Pieter R. Cullis,Carl R. Alving +7 more
TL;DR: It is concluded that complement channels are only transiently open in liposomes, and that loss of channel patency may be due to either channel closing or to loss of channels.