P
Pilar Barrera
Researcher at Radboud University Nijmegen Medical Centre
Publications - 110
Citations - 7649
Pilar Barrera is an academic researcher from Radboud University Nijmegen Medical Centre. The author has contributed to research in topics: Rheumatoid arthritis & Arthritis. The author has an hindex of 47, co-authored 110 publications receiving 7197 citations. Previous affiliations of Pilar Barrera include Radboud University Nijmegen.
Papers
More filters
Journal ArticleDOI
A clinical trial of CTLA-4 blockade with tremelimumab in patients with hepatocellular carcinoma and chronic hepatitis C.
Bruno Sangro,Carlos Gomez-Martin,Manuel de la Mata,Mercedes Iñarrairaegui,Elena Garralda,Pilar Barrera,Jose I Riezu-Boj,Esther Larrea,Carlos Alfaro,Pablo Sarobe,Juan José Lasarte,Jose Luis Perez-Gracia,Ignacio Melero,Ignacio Melero,Jesús Prieto,Jesús Prieto +15 more
TL;DR: Tremelimumab safety profile and antitumor and antiviral activity, in patients with advanced HCC developed on HCV-induced liver cirrhosis, support further investigation.
Journal ArticleDOI
New susceptibility locus for rheumatoid arthritis suggested by a genome-wide linkage study
François Cornelis,Sabine Fauré,Maria Martinez,Jean-François Prud'homme,P Fritz,Colette Dib,Helena Alves,Pilar Barrera,Niek de Vries,Alejandro Balsa,Dora Pascual-Salcedo,Kristin Maenaut,Rene Westhovens,Paola Migliorini,Tuyet-Hoa Tran,A Delaye,Nathalie Prince,Caroline Lefèvre,Gaëlle Thomas,Murielle Poirier,Stéphane Soubigou,Olivier Alibert,Sandra Lasbleiz,Sylvaine Fouix,Christiane Bouchier,Frédéric Lioté,Marie-Noëlle Loste,Virginia Lepage,Dominique Charron,Gabor Gyapay,A. Lopes-Vaz,D. Kuntz,Thomas Bardin,Jean Weissenbach +33 more
TL;DR: This first genome scan in RA Caucasian families revealed 14 candidate regions, one of which was supported further by the study of a second set of families, and could account for 16% of the genetic component of RA.
Journal ArticleDOI
Expression and activity of citrullinating peptidylarginine deiminase enzymes in monocytes and macrophages
Erik R. Vossenaar,Timothy R D J Radstake,A van der Heijden,M A M van Mansum,Cindy E.J. Dieteren,D-J R A M de Rooij,Pilar Barrera,Albert J.W. Zendman,W. J. Van Venrooij +8 more
TL;DR: PAD2 and PAD4 are the most likely candidate PAD isotypes for thecitrullination of synovial proteins in RA and the results indicate that citrullinated vimentin is a candidate autoantigen in RA.
Journal ArticleDOI
IL-32, a proinflammatory cytokine in rheumatoid arthritis.
Leo A. B. Joosten,Mihai G. Netea,Soohyun Kim,Do-Young Yoon,Birgitte Oppers-Walgreen,Timothy R D J Radstake,Pilar Barrera,Fons A. J. van de Loo,Charles A. Dinarello,Wim B. van den Berg +9 more
TL;DR: IL-32, strongly associated with TNFalpha, IL-1beta, and IL-18, appears to play a role in human RA and may be a novel target in autoimmune diseases.
Journal ArticleDOI
Expression of toll-like receptors 2 and 4 in rheumatoid synovial tissue and regulation by proinflammatory cytokines interleukin-12 and interleukin-18 via interferon-gamma.
Timothy R D J Radstake,Mieke F. Roelofs,Yvonne M Jenniskens,Birgitte Oppers-Walgreen,Piet L. C. M. van Riel,Pilar Barrera,Leo A. B. Joosten,Wim B. van den Berg +7 more
TL;DR: TLR-2 and TLR-4 are expressed in synovial tissue of patients with clinically active disease and are associated with the levels of both IL-12 and IL-18, indicating a role for IFNgamma.