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Esther Larrea
Researcher at University of Navarra
Publications - 66
Citations - 3114
Esther Larrea is an academic researcher from University of Navarra. The author has contributed to research in topics: Interferon & Hepatitis C virus. The author has an hindex of 27, co-authored 63 publications receiving 2739 citations. Previous affiliations of Esther Larrea include Chartered Institute of Management Accountants.
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Journal ArticleDOI
A clinical trial of CTLA-4 blockade with tremelimumab in patients with hepatocellular carcinoma and chronic hepatitis C.
Bruno Sangro,Carlos Gomez-Martin,Manuel de la Mata,Mercedes Iñarrairaegui,Elena Garralda,Pilar Barrera,Jose I Riezu-Boj,Esther Larrea,Carlos Alfaro,Pablo Sarobe,Juan José Lasarte,Jose Luis Perez-Gracia,Ignacio Melero,Ignacio Melero,Jesús Prieto,Jesús Prieto +15 more
TL;DR: Tremelimumab safety profile and antitumor and antiviral activity, in patients with advanced HCC developed on HCV-induced liver cirrhosis, support further investigation.
Journal ArticleDOI
Tumor necrosis factor alpha gene expression and the response to interferon in chronic hepatitis C
TL;DR: There is an enhanced expression of TNF-alpha in HCV infection and high levels of this cytokine may play a role in the resistance to interferon therapy.
Journal ArticleDOI
N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB
Petra Van Damme,Marta Lasa,Bogdan Polevoda,Cristina Gazquez,Alberto Elosegui-Artola,Duk Soo Kim,Elena M. De Juan-Pardo,Kimberly Demeyer,Kristine Hole,Esther Larrea,Evy Timmerman,Jesús Prieto,Thomas Arnesen,Fred Sherman,Kris Gevaert,Rafael Aldabe +15 more
TL;DR: Overall, combining quantitative N-terminomics with yeast studies and knockdown of hNatB in human cell lines led to the unambiguous identification of 180 human and 110 yeast NatB substrates, Interestingly, these substrates included Met-Gln- N- termini, which are thus now classified as in vivo NatB substrateates.
Journal ArticleDOI
Upregulation of Indoleamine 2,3-Dioxygenase in Hepatitis C Virus Infection
Esther Larrea,Jose I Riezu-Boj,Lucía Gil-Guerrero,Noelia Casares,Rafael Aldabe,Pablo Sarobe,Maria P. Civeira,Jonathan L. Heeney,Christine S. Rollier,Babs E. Verstrepen,Takaji Wakita,Francisco Borrás-Cuesta,Juan José Lasarte,Jesús Prieto +13 more
TL;DR: In infected chimpanzees, hepatic IDO expression decreased in animals that cured the infection, while it remained high in those that progressed to chronicity, and induction of IDO may dampen T-cell reactivity to viral antigens in chronic HCV infection.
N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB
P. Van Damme,Marta Lasa,Bogdan Polevoda,Cristina Gazquez,Alberto Elosegui-Artola,Dong Soo Kim,E.M. de Juan Pardo,Kimberly Demeyer,Kristine Hole,Esther Larrea,Evy Timmerman,Javier Prieto,Thomas Arnesen,Fred Sherman,Kris Gevaert,Rafael Aldabe +15 more
TL;DR: In this article, the evolutionary traits of NATB from yeast to human and demonstrate that ectopically expressed hNatB-Δ yeast strain partially complements the natBΔ phenotypes and partially restores the yNatB Nt-acetylome.