Virginia Lepage

TL;DR: This first genome scan in RA Caucasian families revealed 14 candidate regions, one of which was supported further by the study of a second set of families, and could account for 16% of the genetic component of RA.

TL;DR: A linkage study based on affected sib pairs suggests that a gene closely linked to the HLA locus confers a greatly increased risk of nasopharyngeal carcinoma.

TL;DR: It is demonstrated that different associations and putative KIR haplotypes could be distinguished in different populations, and no correlation was found between the polymorphism of the KIR genes and the HLA specificities of the tested samples.

TL;DR: negative effects of HLA mismatching for either HLA-A, -B, -C, -DRB1, or -DQB1 loci on survival are demonstrated, and "Missing killer cell immunoglobulin-like receptor (KIR) ligand" evaluated on the presence of Hla-C2, and Bw4 groups in the recipients was not associated with aGVHD, survival, and relapse in this cohort of non-T cell-depleted HS

TL;DR: The absence of a difference in disease severity between groups 2 and 3, as well as the restricted association of HLA-DRB1*03 in group 3, strongly suggest that HLA alleles predispose to autoantibody secretion, without being associated with clinical outcome.