Ping Tai

TL;DR: E2 is a potential physiological regulatory factor for the peripheral development of CD4+CD25+ Treg cells during the implantation period in mice and the results demonstrate that E2, at physiological doses, stimulated the conversion ofCD4+ CD25− T cells into CD4-CD25- T cells which exhibited enhanced Foxp3 and IL‐10 expression in vitro.

TL;DR: It is demonstrated that P4 is an important regulator of systemic and local CD4(+)CD25(+) Treg cells, which are involved in maintaining maternal-fetal immune tolerance during midterm pregnancy.

TL;DR: Results show that activation of the LHR inhibits apoptosis in Leydig cells and that it does so through stimulation of the ERK1/2 pathway, and that the proliferative and antiapoptotic actions of IGF-I are mediated entirely by the Akt pathway.

TL;DR: These studies show that deletion of MEK1/2 in Leydig cells results inLeydig cell hypoplasia, hypoandrogenemia, and reduced fertility.

TL;DR: The results supported that endogenously produced EGFR activator(s), possibly AR and EGFR activation, in cumulus cells is necessary for FSH-induced porcine oocyte meiotic resumption, and suggested that EGFRactivation, by PKC signal pathway, participates in F SHS-induced Porcine Oocyte meiosis resumption.