P
Pithi Chanvorachote
Researcher at Chulalongkorn University
Publications - 217
Citations - 4635
Pithi Chanvorachote is an academic researcher from Chulalongkorn University. The author has contributed to research in topics: Cancer cell & Cancer. The author has an hindex of 31, co-authored 182 publications receiving 3557 citations. Previous affiliations of Pithi Chanvorachote include West Virginia University.
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Journal ArticleDOI
Silver nanoparticles induce toxicity in A549 cells via ROS-dependent and ROS-independent pathways
Porntipa Chairuangkitti,Somsong Lawanprasert,Sittiruk Roytrakul,Sasitorn Aueviriyavit,Duangkamol Phummiratch,Kornphimol Kulthong,Pithi Chanvorachote,Rawiwan Maniratanachote +7 more
TL;DR: Observations allow us to propose that the in vitro toxic effects of AgNPs on A549 cells are mediated via both ROS-dependent (cytotoxicity) and ROS-independent (cell cycle arrest) pathways.
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Reactive Oxygen Species Mediate Caspase Activation and Apoptosis Induced by Lipoic Acid in Human Lung Epithelial Cancer Cells through Bcl-2 Down-Regulation
Jirapan Moungjaroen,Ubonthip Nimmannit,Patrick S. Callery,Liying Wang,Neelam Azad,Vimolmas Lipipun,Pithi Chanvorachote,Yon Rojanasakul +7 more
TL;DR: A novel pro-oxidant role of LA is indicated in apoptosis induction and its regulation by Bcl-2, which may be exploited for the treatment of cancer and related apoptosis disorders.
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Regulation of Lung Cancer Cell Migration and Invasion by Reactive Oxygen Species and Caveolin-1
Sudjit Luanpitpong,Siera Jo Talbott,Yon Rojanasakul,Ubonthip Nimmannit,Varisa Pongrakhananon,Liying Wang,Pithi Chanvorachote +6 more
TL;DR: It is demonstrated here that Cav-1 plays an important role in the migration and invasion of human lung carcinoma H460 cells and that these effects are differentially regulated by cellular ROS.
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Nitric Oxide Regulates Cell Sensitivity to Cisplatin-Induced Apoptosis through S-Nitrosylation and Inhibition of Bcl-2 Ubiquitination
Pithi Chanvorachote,Ubonthip Nimmannit,Christian Stehlik,Liying Wang,Bing-Hua Jiang,Boonsri Ongpipatanakul,Yon Rojanasakul +6 more
TL;DR: It is shown that NO impairs the apoptotic function of cells and increases their resistance to cisplatin-induced cell death in human lung carcinoma H-460 cells, indicating a novel pathway for NO regulation of Bcl-2, which provides a key mechanism for cisPlatin resistance and its potential modulation for improved cancer chemotherapy.
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Nitric oxide negatively regulates Fas CD95-induced apoptosis through inhibition of ubiquitin-proteasome-mediated degradation of FLICE inhibitory protein
Pithi Chanvorachote,Ubonthip Nimmannit,Liying Wang,Christian Stehlik,Bin Lu,Neelam Azad,Yon Rojanasakul +6 more
TL;DR: It is shown that stimulation of the Fas receptor by its ligand (FasL) results in rapid generation of NO and concomitant decrease in cellular FLICE inhibitory protein (FLIP) expression without significant effect on Fas and Fas-associated death domain (FADD) adapter protein levels, indicating a novel pathway for NO regulation of FLIP.