Journal ArticleDOI
Silver nanoparticles induce toxicity in A549 cells via ROS-dependent and ROS-independent pathways
Porntipa Chairuangkitti,Somsong Lawanprasert,Sittiruk Roytrakul,Sasitorn Aueviriyavit,Duangkamol Phummiratch,Kornphimol Kulthong,Pithi Chanvorachote,Rawiwan Maniratanachote +7 more
TLDR
Observations allow us to propose that the in vitro toxic effects of AgNPs on A549 cells are mediated via both ROS-dependent (cytotoxicity) and ROS-independent (cell cycle arrest) pathways.About:
This article is published in Toxicology in Vitro.The article was published on 2013-02-01. It has received 237 citations till now. The article focuses on the topics: Viability assay & A549 cell.read more
Citations
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Journal ArticleDOI
Mechanisms of nanoparticle-induced oxidative stress and toxicity.
TL;DR: Through physicochemical characterization and understanding of the multiple signaling cascades activated by NP-induced ROS, a systemic toxicity screen with oxidative stress as a predictive model for NP- induced injury can be developed.
Journal ArticleDOI
Microplastic Size-Dependent Toxicity, Oxidative Stress Induction, and p-JNK and p-p38 Activation in the Monogonont Rotifer (Brachionus koreanus)
Chang-Bum Jeong,Chang-Bum Jeong,Eun-Ji Won,Eun-Ji Won,Hye-Min Kang,Min-Chul Lee,Dae-Sik Hwang,Un Ki Hwang,Bingsheng Zhou,Sami Souissi,Su Jae Lee,Jae-Seong Lee +11 more
TL;DR: In vitro tests revealed that antioxidant-related enzymes and MAPK signaling pathways were significantly activated in response to microplastic exposure in a size-dependent manner, suggesting that 6-μm microbeads are more effectively egested from B. koreanus than 0.05- or 0.5- μm microBeads.
Journal ArticleDOI
Molecular toxicity mechanism of nanosilver
TL;DR: This review summarizes recent advances, particularly the molecular mechanism of nanosilver toxicity, which causes oxidative stress through the generation of reactive oxygen species and causes damage to cellular components.
Journal ArticleDOI
Silver nanoparticle protein corona and toxicity: a mini-review
TL;DR: The main aim of this mini-review is to highlight the relationship between the formation of silver nanoparticle protein coronas and toxicity.
Journal ArticleDOI
Silver Nanoparticles: Technological Advances, Societal Impacts, and Metrological Challenges.
Bryan Calderón-Jiménez,Monique E. Johnson,Antonio R. Montoro Bustos,Karen E. Murphy,Michael R. Winchester,Jose R. Vega Baudrit +5 more
TL;DR: An overview of the commercial, societal, and environmental impacts of this emerging nanoparticle (NP), and nanomaterials in general is presented and the importance of the development of NP reference materials (RMs) is discussed.
References
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Journal ArticleDOI
Toxic Potential of Materials at the Nanolevel
TL;DR: The establishment of principles and test procedures to ensure safe manufacture and use of nanomaterials in the marketplace is urgently required and achievable.
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Antimicrobial effects of silver nanoparticles
Jun Sung Kim,Eunye Kuk,Kyeong Nam Yu,Jong-Ho Kim,Sungjin Park,Hu Jang Lee,So Hyun Kim,Young Kyung Park,Yong Ho Park,Cheol Yong Hwang,Yong-Kwon Kim,Yoon-Sik Lee,Dae Hong Jeong,Myung-Haing Cho +13 more
TL;DR: The results suggest that Ag nanoparticles can be used as effective growth inhibitors in various microorganisms, making them applicable to diverse medical devices and antimicrobial control systems.
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Cytotoxicity and Genotoxicity of Silver Nanoparticles in Human Cells
TL;DR: A possible mechanism of toxicity is proposed which involves disruption of the mitochondrial respiratory chain by Ag-np leading to production of ROS and interruption of ATP synthesis, which in turn cause DNA damage.
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In vitro toxicity of nanoparticles in BRL 3A rat liver cells
TL;DR: The microscopic studies demonstrated that nanoparticle-exposed cells at higher doses became abnormal in size, displaying cellular shrinkage, and an acquisition of an irregular shape, which suggested that cytotoxicity of Ag (15, 100 nm) in liver cells is likely to be mediated through oxidative stress.
Journal ArticleDOI
Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage.
Ning Li,Constantinos Sioutas,Arthur K. Cho,Debra A. Schmitz,Chandan Misra,Joan M. Sempf,Meiying Wang,Terry D. Oberley,John R. Froines,Andre E. Nel +9 more
TL;DR: The studies demonstrate that the increased biological potency of UFPs is related to the content of redox cycling organic chemicals and their ability to damage mitochondria.