Pooja Khatkar

TL;DR: A major sub‐pathway of conventional long‐patch BER that involves formation of a 9‐nucleotide gap 5′ to the lesion is discovered and is mediated by RECQ1 DNA helicase and ERCC1‐XPF endonuclease in cooperation with PARP1 poly(ADP‐ribose) polymerase and RPA.

TL;DR: In-cell and in vitro mechanism studies revealed that this delay in repair was due to inefficient turnover of N-methylpurine-DNA glycosylase (MPG), which initiates BER of εA, suggesting a previously unknown mechanism for slower repair at mutation hotspots and implicating sequence-related variability of DNA repair efficiency to be responsible for mutation hotspot signatures.

TL;DR: The data suggest that CBD significantly reduces the number of EVs released from infected cells and that this may be mediated by reducing viral transcription and autophagy activation, which may exert a protective effect by alleviating the pathogenic effects of EVs in HIV-1 and CNS-related infections.

TL;DR: In this paper , the authors reported the generation of neurospheres from iPSC-derived neural progenitor cells (NPCs) and showed that these cultures are permissive to retroviral (e.g. HIV-1, HTLV-1) replication.

TL;DR: This microscopy-based methodology is reliable in detecting the recruitment of proteins to specific DNA substrates and can be extended to study other in vivo DNA-protein relationships in any DNA sequence and in the context of any DNA structure in transfectable proliferating or quiescent cells.