Poornima Sharma

TL;DR: The metabolic transformation of antirheumatic fluorescent drug leflunomid into its active metabolite teriflunomide through isoxazole ring opening has been monitored in vitro using steady state and time domain fluorescence spectroscopy and density functional theory to reveal slow conversion of lefl UNO to E and Z forms in aqueous medium, which becomes faster at basic pH.

TL;DR: In this article, the presence and conversion of α to β polymorphic forms of an anti-rheumatic drug leflunomide have been studied by temperature-dependent and in situ Raman observations.

TL;DR: The α and γ polymorphs of drug pyrazinamide have been detected with the help of temperature dependent Raman spectroscopic technique and polymorphic phase change from α→γ form of pyrazine between 145 and 146°C is suggested.

TL;DR: The findings demonstrate hepatoprotective, immunomodulatory and anti-carcinogenic effects and suggest the use of mushrooms as potential dietary prophylactics in cancer chemoprevention.

TL;DR: Correlation of the theoretically calculated results with experimental Raman spectral analysis has led to a detailed and proper understanding of this important biochemical reaction.