Prabhu Thirusangu

TL;DR: In vivo antitumor effect of compound 5c against murine EAC and solid DL tumor model system was evident by the extended survivality and the tumor inhibitory mechanism of compounds 5c was due to the antiangiogenesis and promotion of apoptosis.

TL;DR: Repurposing quinacrine as an anticancer agent appears to be a promising strategy based on its ability to target multiple pathways, its selectivity against cancer cells, and the synergistic cytotoxicity when combined with other anticancer agents with limited side effects and good tolerability profile.

TL;DR: It is concluded that BP-1T acts on HIF-1α degradation through p53/MDM2 proteasome pathway, eventually leading to abolition of migration and invasion in solid tumour.

TL;DR: Analyzing the structure-activity relationship, it is found that an increase in the number of methyl groups in addition to methoxy substitution at the para position of the benzoyl ring in compound 8n resulted in higher potency compared to 8f.

TL;DR: Experimental data showed that compound 13f induces the apoptotic cell death by activating apoptotic factors such as caspase-8 &-3, CAD, Cleaved PARP, γ-H2AX and by degrading genomic DNA of cancer cells and thereby decreasing the ascitic tumour development in mice.