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Pradeep K. Sharma
Researcher at Johnson Matthey
Publications - 15
Citations - 171
Pradeep K. Sharma is an academic researcher from Johnson Matthey. The author has contributed to research in topics: Alkyl & Swainsonine. The author has an hindex of 8, co-authored 15 publications receiving 158 citations.
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Journal ArticleDOI
Scale-Up Syntheses of Two Naturally Occurring Procyanidins: (−)-Epicatechin-(4β,8)-(+)-catechin and (−)-Epicatechin-3-O-galloyl-(4β,8)-(−)-epicatechin-3-O-gallate†
Pradeep K. Sharma,Alexander G. Kolchinski,Helene A. Shea,Jayesh J. Nair,Yanni Gou,Leo J. Romanczyk,Harold H. Schmitz +6 more
TL;DR: In this article, a scaleable process for the synthesis of two naturally occurring procyanidins, namely (−)-epicatechin-(4β,8)-(+)-catechin (1) and (−)-propagation-3-O-galloyl (2), is described.
Journal ArticleDOI
Scale-Up Synthesis of Swainsonine: A Potent α-Mannosidase II Inhibitor†
TL;DR: In this article, a large-scale synthesis of Swainsonine 1, a potent α-mannosidase II inhibitor, has been achieved with several improvements, including Wittig olefination under mild conditions and isolation of the product with modified workup conditions.
Journal ArticleDOI
A versatile approach to the regioselective synthesis of diverse (−)-epicatechin-β-d-glucuronides
Eric Mull,Michael C. Van Zandt,Adam Golebiowski,Paul Beckett,Pradeep K. Sharma,Hagen Schroeter +5 more
TL;DR: In this article, a versatile new approach for the total synthesis of five glucuronide metabolites of epicatechin, using selective protection/deprotection techniques, was reported for the first time.
Journal ArticleDOI
Enantioselctive syntheses of sulfur analogues of flavan-3-Ols.
Pradeep K. Sharma,Min He,Jurjus Jurayj,Daming Gou,Lombardy Richard John,Leo J. Romanczy,Hagen Schroeter +6 more
TL;DR: The first enantioselective syntheses of sulfur flavan-3-ol analogues 1–8 have been accomplished, whereby the oxygen atom of the pyran ring has been replaced by a sulfur atom.
Journal ArticleDOI
Total Synthesis of Proanthocyanidin A1, A2, and Their Stereoisomers
Pradeep K. Sharma,Leo J. Romanczyk,Leelakrishna Kondaveti,Bollu Reddy,Jeeva Arumugasamy,Lombardy Richard John,Yanni Gou,Hagen Schroeter +7 more
TL;DR: Following this methodology, an additional six diastereomers of proanthocyanidins A1 and A2 have been synthesized and a plausible mechanism for the formation of the A-type linkage in proantho-epicatechin has been proposed.