P
Pradeep K. Singh
Researcher at University of Washington
Publications - 199
Citations - 17478
Pradeep K. Singh is an academic researcher from University of Washington. The author has contributed to research in topics: Pseudomonas aeruginosa & Enantioselective synthesis. The author has an hindex of 54, co-authored 166 publications receiving 15002 citations. Previous affiliations of Pradeep K. Singh include University of Washington Medical Center & Roy J. and Lucille A. Carver College of Medicine.
Papers
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Journal ArticleDOI
Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms
Pradeep K. Singh,Amy L. Schaefer,Matthew R. Parsek,Thomas O. Moninger,Michael J. Welsh,E. P. Greenberg +5 more
TL;DR: The hypothesis that P. aeruginosa might exist as biofilms—structured communities of bacteria encased in a self-produced polymeric matrix—in the cystic fibrosis lung is supported by microscopy of cystic Fibrosis sputum, which shows that the bacterium are in biofilm-like structures.
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Bacterial Biofilms: An Emerging Link to Disease Pathogenesis
TL;DR: This chapter discusses three infections that are caused by biofilms--infectious kidney stones, bacterial endocarditis, and cystic fibrosis lung infections--and focuses on the role of the biofilm in disease pathogenesis.
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A component of innate immunity prevents bacterial biofilm development
Pradeep K. Singh,Matthew R. Parsek,E. Peter Greenberg,E. Peter Greenberg,Michael J. Welsh,Michael J. Welsh,Michael J. Welsh +6 more
TL;DR: It is shown that lactoferrin, a ubiquitous and abundant constituent of human external secretions, blocks biofilm development by the opportunistic pathogen Pseudomonas aeruginosa at concentrations below those that kill or prevent growth.
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Active Starvation Responses Mediate Antibiotic Tolerance in Biofilms and Nutrient-Limited Bacteria
Dao Nguyen,Amruta Joshi-Datar,François Lépine,Elizabeth Bauerle,Oyebode Olakanmi,Karlyn D. Beer,Geoffrey McKay,Richard Siehnel,James Schafhauser,Yun Wang,Bradley E. Britigan,Bradley E. Britigan,Pradeep K. Singh +12 more
TL;DR: The experiments link SR-mediated tolerance to reduced levels of oxidant stress in bacterial cells, and inactivating this protective mechanism sensitized biofilms by several orders of magnitude to four different classes of antibiotics and markedly enhanced the efficacy of antibiotic treatment in experimental infections.
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Self-generated diversity produces “insurance effects” in biofilm communities
TL;DR: It is shown that the opportunistic pathogen Pseudomonas aeruginosa undergoes extensive genetic diversification during short-term growth in biofilm communities, suggesting that self-generated diversity in biofilms provides a form of biological insurance that can safeguard the community in the face of adverse conditions.