P
Prasenjit Mitra
Researcher at University of Hyderabad
Publications - 28
Citations - 1013
Prasenjit Mitra is an academic researcher from University of Hyderabad. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 12, co-authored 20 publications receiving 948 citations. Previous affiliations of Prasenjit Mitra include University of Massachusetts Amherst & University of Massachusetts Medical School.
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Journal ArticleDOI
A Role for Nuclear PTEN in Neuronal Differentiation
Mahesh Lachyankar,Nazneen Sultana,Christopher M. Schonhoff,Prasenjit Mitra,Wojciech Poluha,Stephen Lambert,Peter J. Quesenberry,N. Scott Litofsky,Lawrence Recht,Roya Nabi,Susan C. Miller,Shinji Ohta,Benjamin G. Neel,Alonzo H. Ross +13 more
TL;DR: Observations indicate that PTEN acts at multiple sites in the cell, regulating the transition of differentiating neuroblasts to postmitotic neurons, and is not required for astrocytic differentiation.
Journal ArticleDOI
RNAi-based analysis of CAP, Cbl, and CrkII function in the regulation of GLUT4 by insulin.
TL;DR: The dose-response relationship for insulin stimulation of deoxyglucose transport in primary adipocytes derived from c-Cbl knock-out mice was identical to insulin action on adipocytes from wild type mice, consistent with the hypothesis that CAP, Cbl iso-forms, and CrkII are not required components of insulin signaling to GLUT4 transporters.
Journal ArticleDOI
Glucagon-like peptide-1 receptor-mediated endosomal cAMP generation promotes glucose-stimulated insulin secretion in pancreatic β-cells
Ramya S. Kuna,Shravan Babu Girada,Suman Asalla,Joyprashant Vallentyne,Subbareddy Maddika,James Patterson,James Patterson,David L. Smiley,Richard D. DiMarchi,Prasenjit Mitra +9 more
TL;DR: A novel functional analog of GLP-1 conjugated to tetramethyl rhodamine is synthesized to monitor the internalization of the receptor and shows that after being internalized the receptor is sorted to lysosomes.
Journal ArticleDOI
Analysis of insulin signalling by RNAi-based gene silencing
Qiong L. Zhou,Jin Park,Zhen Y. Jiang,John Holik,Prasenjit Mitra,Sabina Semiz,Adilson L. Guilherme,Aimee M. Powelka,Xiaoqing Tang,Joseph V. Virbasius,Michael P. Czech +10 more
TL;DR: Results show that Akt2/PKBbeta is the key downstream intermediate within the phosphoinositide 3-kinase pathway linked to insulin action on GLUT4 in cultured adipocytes, whereas PTEN is a potent negative regulator of this pathway.
Journal ArticleDOI
A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast
Prasenjit Mitra,Yingjie Zhang,Lucia E. Rameh,Mariya Ivshina,Dannel McCollum,John J. Nunnari,Gregory M. Hendricks,Monica L. Kerr,Seth J. Field,Lewis C. Cantley,Alonzo H. Ross +10 more
TL;DR: Surprisingly, upon deletion of ptn1 in S. pombe, PI(3,4,5)P3 became detectable at levels comparable to those in mammalian cells, indicating that a pathway exists for synthesis of this lipid and that the S.pombe ptn 1, like mammalian PTEN, suppresses PI(2,3,5), which is suggested to have evolved before the appearance of class I phosphoinositide 3-kinases.