W
Wojciech Poluha
Researcher at Worcester Foundation for Biomedical Research
Publications - 9
Citations - 772
Wojciech Poluha is an academic researcher from Worcester Foundation for Biomedical Research. The author has contributed to research in topics: Nerve growth factor & Cell growth. The author has an hindex of 6, co-authored 9 publications receiving 762 citations. Previous affiliations of Wojciech Poluha include University of Massachusetts Medical School.
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Journal ArticleDOI
The cyclin-dependent kinase inhibitor p21 (WAF1) is required for survival of differentiating neuroblastoma cells.
Wojciech Poluha,Dorota K. Poluha,Baochong Chang,Nancy E. Crosbie,Christopher M. Schonhoff,Daniel L. Kilpatrick,Andalonzo H. Ross +6 more
TL;DR: The data indicate that p21WAF1 expression is required for survival of these differentiating neuroblastoma cells, and the problem of neuronal differentiation can now be understood in the context of negative regulators of the cell cycle.
Journal ArticleDOI
A Role for Nuclear PTEN in Neuronal Differentiation
Mahesh Lachyankar,Nazneen Sultana,Christopher M. Schonhoff,Prasenjit Mitra,Wojciech Poluha,Stephen Lambert,Peter J. Quesenberry,N. Scott Litofsky,Lawrence Recht,Roya Nabi,Susan C. Miller,Shinji Ohta,Benjamin G. Neel,Alonzo H. Ross +13 more
TL;DR: Observations indicate that PTEN acts at multiple sites in the cell, regulating the transition of differentiating neuroblasts to postmitotic neurons, and is not required for astrocytic differentiation.
Journal ArticleDOI
A novel, nerve growth factor-activated pathway involving nitric oxide, p53, and p21WAF1 regulates neuronal differentiation of PC12 cells
Wojciech Poluha,Christopher M. Schonhoff,Kimberly Stacy Harrington,Mahesh B. Lachyankar,Nancy E. Crosbie,Dylan A. Bulseco,Alonzo H. Ross +6 more
TL;DR: A signal transduction pathway is identified that is activated by NGF; proceeds through NOS, p53, and p21WAF1 to block cell proliferation; and is required for neuronal differentiation by PC12 cells.
Journal Article
Neuronal differentiation triggered by blocking cell proliferation.
Patrizia C O Molecula Lopresti,Wojciech Poluha,Dorota K. Poluha,Elizabeth Drinkwater,Alonzo H. Ross +4 more
TL;DR: It is concluded that aphidicolin, hydroxyurea, and thymidine enhance NGF-induced differentiation by blocking cell proliferation and not through an unrelated side effect.
Journal Article
TrkA neurogenic receptor regulates differentiation of neuroblastoma cells.
TL;DR: In this paper, the authors examined events associated with neuronal differentiation of neuroblastoma cell line SH-SY5Y and found that NGF and aphidicolin, an inhibitor of DNA polymerases alpha and delta, induces terminal differentiation of SH-Sy5Y cells.