P
Pravinkumar B. Sehgal
Researcher at Rockefeller University
Publications - 106
Citations - 11132
Pravinkumar B. Sehgal is an academic researcher from Rockefeller University. The author has contributed to research in topics: Interferon & Gene. The author has an hindex of 58, co-authored 103 publications receiving 10934 citations. Previous affiliations of Pravinkumar B. Sehgal include New York Medical College & Yale University.
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Journal ArticleDOI
Interleukin 6 is expressed in high levels in psoriatic skin and stimulates proliferation of cultured human keratinocytes.
Rachel Grossman,James G. Krueger,Debra Yourish,Angela Granelli-Piperno,Daniel P. Murphy,Lester T. May,Thomas S. Kupper,Pravinkumar B. Sehgal,Alice B. Gottlieb +8 more
TL;DR: Interleukin 6 could directly contribute to the epidermal hyperplasia seen in psoriatic epithelium as well as affect the function of dermal inflammatory cells.
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Induction of β2-interferon by tumor necrosis factor: A homeostatic mechanism in the control of cell proliferation
TL;DR: It is demonstrated that purified E. coli-derived recombinant human TNF inhibits encephalomyocarditis virus replication in "aged" human fibroblasts, suggesting that IFN-beta 2 has biological functions distinct from the other interferons.
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A comparative study of the diagnostic performance of amniotic fluid glucose, white blood cell count, interleukin-6, and Gram stain in the detection of microbial invasion in patients with preterm premature rupture of membranes***
Roberto Romero,Bo Hyun Yoon,Moshe Mazor,Ricardo Gomez,Rogelio Gonzalez,Michael P. Diamond,Peter Baumann,Heriberto Araneda,John S. Kenney,David B. Cotton,Pravinkumar B. Sehgal +10 more
TL;DR: Interleukin-6 concentrations in amniotic fluid are a better predictor of microbial invasion of the amniotics cavity, amniocentesis-to-delivery interval and neonatal complications than the ammiotic fluid Gram stain, glucose, or white blood cell count in patients with preterm premature rupture of membranes.
Journal ArticleDOI
Repression of the interleukin 6 gene promoter by p53 and the retinoblastoma susceptibility gene product.
TL;DR: Transient transfection experiments suggest that p53 and RB may be involved as transcriptional repressors in modulating IL-6 gene expression during cellular differentiation and oncogenesis.
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The diagnostic and prognostic value of amniotic fluid white blood cell count, glucose, interleukin-6, and Gram stain in patients with preterm labor and intact membranes
Roberto Romero,Bo Hyun Yoon,Moshe Mazor,Ricardo Gomez,Michael P. Diamond,John S. Kenney,Marcelo Ramirez,Paul L. Fidel,Yoram Sorokin,David B. Cotton,Pravinkumar B. Sehgal +10 more
TL;DR: Interleukin-6 concentrations in amniotic fluid are better indicators of microbial invasion of the amniotics cavity, amniocentesis-to-delivery interval, and neonatal complications than the ammiotic fluid Gram stain, glucose concentration, or white blood cell count.