Pulak R. Manna

TL;DR: It is demonstrated unequivocally that StAR mRNA and protein are expressed within glia and neurons in discrete regions of the mouse brain, and that glial StAR expression is inducible, and this data support a role for StAR in the production of neurosteroids and identify potential sites of active de novo steroid synthesis in the brain.

TL;DR: A regulatory cascade of thyroid hormone-stimulated StAR expression and steroidogenesis that provides novel insight into the importance of a thyroid-gonadal connection in the hormonal control of Leydig cell steroidogenesis is identified.

TL;DR: A dual response mechanism of T(3) on steroidogenesis and StAR expression, and on LH receptor (LHR) expression and binding in mLTC-1 cells is reported, which further characterize the thyroid-gonadal connection and provide insights into the mechanisms for a dual regulatory role of thyroid hormone in Leydig cell functions.

TL;DR: Evidence is provided that extracellular calcium (Ca2+) regulates the hCG-stimulated expression of StAR protein and steroidogenesis in a mouse Leydig tumor cell line and indicates the requirement for on-going protein synthesis for hCG action.

TL;DR: This particular mutation in the conserved extracellular region of glycoprotein hormone receptors induces a conformational change that suppresses cell membrane targeting of the mutated receptor, probably through altered intracellular folding.