P
Purvi Bhatt
Researcher at Narsee Monjee Institute of Management Studies
Publications - 17
Citations - 286
Purvi Bhatt is an academic researcher from Narsee Monjee Institute of Management Studies. The author has contributed to research in topics: Oxidative stress & Oviduct. The author has an hindex of 9, co-authored 16 publications receiving 214 citations. Previous affiliations of Purvi Bhatt include National Institute for Research in Reproductive Health & Indian Council of Medical Research.
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Arsenic trioxide: insights into its evolution to an anticancer agent
TL;DR: The ability of arsenic, specifically arsenic trioxide, to treat acute promyelocytic leukaemia has radically changed the perception of this poison and has been the main factor for the re-emergence of this candidate to Western medicine for the treatment of leukaems and other solid tumours.
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Specific domains of nucleolin interact with Hdm2 and antagonize Hdm2-mediated p53-ubiquitination
TL;DR: The data suggest that changes in nucleolin conformation can alter the availabilities of such domains in’vivo to modulate the overall impact of nucleolin on Hdm2 activity and hence on p53 stability.
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Biocompatible arsenic trioxide nanoparticles induce cell cycle arrest by p21(WAF1/CIP1) expression via epigenetic remodeling in LNCaP and PC3 cell lines.
TL;DR: The results demonstrate that the nanoparticulate formulation of dimercaptosuccinic acid and chitosan coated As2O3 is capable of inducing morphological changes, DNA damage and caspase-dependent apoptosis along with the expression of cyclin-dependent kinase inhibitor p21 by upregulation of Bax and downregulation ofBcl-2 and Bcl-xL proteins.
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Ultraviolet-B Protective Effect of Flavonoids from Eugenia caryophylata on Human Dermal Fibroblast Cells
Juilee Patwardhan,Purvi Bhatt +1 more
TL;DR: The findings suggested that the flavonoids from clove could potentially be considered as UV-B protectants and can be explored further for its topical application to the area of the skin requiring protection.
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Investigation of HSA as a biocompatible coating material for arsenic trioxide nanoparticles
Maneka Hoonjan,Geetanjali Sachdeva,Sudeshna Chandra,Prashant S. Kharkar,Niteshkumar Sahu,Purvi Bhatt +5 more
TL;DR: The development of a protein-based delivery system for As2O3 with improved biocompatibility is reported, and molecular simulation studies provided evidence of interaction between HSA and As2 O3.