Q
Q. Yan
Researcher at University of Nebraska Medical Center
Publications - 8
Citations - 416
Q. Yan is an academic researcher from University of Nebraska Medical Center. The author has contributed to research in topics: Apoptosis & Phosphorylation. The author has an hindex of 8, co-authored 8 publications receiving 386 citations. Previous affiliations of Q. Yan include Hunan Normal University & University of Pennsylvania.
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Journal ArticleDOI
Apoptosis in lens development and pathology.
TL;DR: Both in vitro and in vivo studies have shown that treatment of adult lens with stress factors induces apoptosis of lens epithelial cells, which is followed by cataractogenesis.
Journal ArticleDOI
Sumoylation activates the transcriptional activity of Pax-6, an important transcription factor for eye and brain development
Q. Yan,Q. Yan,Lili Gong,Mi Deng,Lan Zhang,Shuming Sun,Shuming Sun,Jiao Liu,Jiao Liu,Haili Ma,D. Yuan,Peichao Chen,Xiao-Hui Hu,Jin Ping Liu,Jichao Qin,Jichao Qin,L. Xiao,L. Xiao,Xiao Qin Huang,Jian Zhang,David W Li,David W Li +21 more
TL;DR: It is shown that sumoylation at K91 is required for p32 Pax-6 to bind to a HD-specific site and regulate expression of target genes, and that p32 and p46 Pax- 6 possess differential DNA-binding and regulatory activities.
Journal ArticleDOI
Nuclear factor-κB binding motifs specify Toll-like receptor-induced gene repression through an inducible repressosome.
Q. Yan,Ruaidhrí J. Carmody,Zhonghua Qu,Qingguo Ruan,Jennifer Jager,Shannon E. Mullican,Mitchell A. Lazar,Youhai H. Chen +7 more
TL;DR: It is reported here that NF-κB binding nucleic acids of gene promoters are tolerogenic motifs, which selectively recruit an NcoR–Hdac3–deacetylated-p50 repressosome to inflammatory genes.
Journal ArticleDOI
Protein Phosphatase-2A Is a Target of Epigallocatechin-3-Gallate and Modulates p53-Bak Apoptotic Pathway
Jichao Qin,Jichao Qin,H.-G. Chen,Q. Yan,Q. Yan,Mi Deng,Jin Ping Liu,Jin Ping Liu,Stephan Doerge,Wei-Ya Ma,Zigang Dong,David W Li,David W Li,David W Li +13 more
TL;DR: EGCG-mediated negative regulation of PP-2A is an important molecular event for the activation of p53-dependent apoptosis during its chemoprevention.
Journal ArticleDOI
Protein phosphatase-1 modulates the function of Pax-6, a transcription factor controlling brain and eye development.
Q. Yan,Q. Yan,Wenbin Liu,Jichao Qin,Jin Ping Liu,H.-G. Chen,H.-G. Chen,Xiaoqin Huang,Lili Chen,Shuming Sun,Mi Deng,Lili Gong,Yong Li,Lan Zhang,Yan Liu,Hao Feng,Yamei Xiao,Yun Liu,David W Li,David W Li +19 more
TL;DR: In vitro and in vivo evidence is presented to show that protein serine/threonine phosphatase-1 is a majorosphatase that directly dephosphorylates Pax-6 and significantly modulates its function in regulating expression of both exogenous and endogenous genes.