M
Mi Deng
Researcher at University of Texas Southwestern Medical Center
Publications - 56
Citations - 1772
Mi Deng is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Myeloid leukemia & Transcription factor. The author has an hindex of 21, co-authored 55 publications receiving 1386 citations. Previous affiliations of Mi Deng include Central South University & University of Texas System.
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Journal ArticleDOI
The basic leucine zipper transcription factor NFIL3 directs the development of a common innate lymphoid cell precursor
TL;DR: It is established thatNFIL3 directs the differentiation of a committed ILC precursor that gives rise to all ILC lineages and provides insight into the defining role of NFIL3 in ILC development.
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LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration
Mi Deng,Xun Gui,Jaehyup Kim,Li Xie,Weina Chen,Zunling Li,Zunling Li,Licai He,Licai He,Yuanzhi Chen,Yuanzhi Chen,Heyu Chen,Weiguang Luo,Weiguang Luo,Zhigang Lu,Zhigang Lu,Jingjing Xie,Jingjing Xie,Hywyn Churchill,Yixiang Xu,Zhan Zhou,Guojin Wu,Chenyi Yu,Chenyi Yu,Samuel John,Kouyuki Hirayasu,Nam X. Nguyen,Xiaoye Liu,Fangfang Huang,Fangfang Huang,Leike Li,Hui Deng,Haidong Tang,Ali H. Sadek,Lingbo Zhang,Lingbo Zhang,Tao Huang,Yizhou Zou,Benjamin P C Chen,Hong Zhu,Hisashi Arase,Ningshao Xia,Youxing Jiang,Robert H. Collins,M. James You,Jade Homsi,Nisha Unni,Cheryl M. Lewis,Guo-Qiang Chen,Yang Xin Fu,X. Charlene Liao,Zhiqiang An,Junke Zheng,Ningyan Zhang,Cheng Cheng Zhang +54 more
TL;DR: It is shown that LILRB4, an immunoreceptor tyrosine-based inhibition motif-containing receptor and a marker of monocytic leukaemia, supports tumour cell infiltration into tissues and suppresses T cell activity via a signalling pathway that involves APOE, LIL RB4, SHP-2, uPAR and ARG1 in acute myeloid leukaemis (AML) cells.
Journal ArticleDOI
Inhibitory leukocyte immunoglobulin-like receptors: Immune checkpoint proteins and tumor sustaining factors.
TL;DR: This review aims to summarize current knowledge on expression patterns, ligands, signaling, and functions of LILRB family members in the context of cancer development and indicates that LIL RBs may represent ideal targets for tumor treatment.
Journal ArticleDOI
The ITIM-containing receptor LAIR1 is essential for acute myeloid leukaemia development
Xunlei Kang,Zhigang Lu,Changhao Cui,Changhao Cui,Mi Deng,Yuqi Fan,Baijun Dong,Xin Han,Fuchun Xie,Jeffrey W. Tyner,John E. Coligan,Robert H. Collins,Xiangshu Xiao,M. James You,Cheng Cheng Zhang +14 more
TL;DR: It is reported that certain receptors containing the immunoreceptor tyrosine-based inhibition motif (ITIM) are crucial for the development of acute myeloid leukaemia (AML) and intervention in the signalling initiated by ITIM-containing receptor LAIR1 may result in successful treatment of AML.
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Protein serine/threonine phosphatase-1 dephosphorylates p53 at Ser-15 and Ser-37 to modulate its transcriptional and apoptotic activities
Dawei Li,Dawei Li,Jin Ping Liu,P. C. Schmid,R. Schlosser,H. Feng,W. B. Liu,Q. Yan,Lili Gong,S. M. Sun,Mi Deng,Yun Liu +11 more
TL;DR: PP-1 can directly dephosphorylate a master regulator of apoptosis, p53, to negatively modulate its transcriptional and apoptotic activities, and thus to promote cell survival and reveal one of the molecular mechanisms by which PP-1 promotes cell survival is to deph phosphatelate p53 and thus negatively regulate p53-dependent death pathway.